The carcinoembryonic antigen (CEA): Past, present, and future
Phil Gold,Neil Goldberg +1 more
TLDR
In this article, the authors proposed a method to solve the problem of "N/A/A" and "A/B/C/D/C" in the problem.Abstract:
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Citations
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Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers
TL;DR: CEACAM6 expression is elevated in many solid tumors, but variable as a function of histotype, and may be a promising target for antibody-based therapy.
Journal ArticleDOI
Inhibition of Adhesion, Invasion, and Metastasis by Antibodies Targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen)
TL;DR: It is shown that antibody Fabs that target either CEACAM5 or CEACam6 affect cell migration, cell invasion, and cell adhesion in vitro, and that MN-15 and MN-3 Fabs have antimetastatic effects in vivo, resulting in improved survival of mice with metastases.
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Carcinoembryonic Antigen as a Target for Therapeutic Anticancer Vaccines: A Review
TL;DR: Tolerance to CEA in patients with cancer can be overcome with several different vaccination approaches, and such vaccinations are safe and immunologically active.
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Phase II Trial of Carcinoembryonic Antigen Radioimmunotherapy With 131I-Labetuzumab After Salvage Resection of Colorectal Metastases in the Liver: Five-Year Safety and Efficacy Results
Torsten Liersch,Johannes Meller,Bettina Kulle,Thomas M. Behr,Peter M. Markus,Claus Langer,B. Michael Ghadimi,William A. Wegener,Jacqueline Kovacs,Ivan Horak,Heinz Becker,David M. Goldenberg +11 more
TL;DR: Both the median OS and 5-year survival rates seem to be improved with adjuvant RAIT after complete LM resection in CRC, compared with historical and contemporaneous controls not receiving RAIT, which justifies further evaluation of this modality in a multicenter, randomized trial.
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Characterization of Genetically Modified T-Cell Receptors that Recognize the CEA:691-699 Peptide in the Context of HLA-A2.1 on Human Colorectal Cancer Cells
Maria R. Parkhurst,Jayne S Joo,John P. Riley,Zhiya Yu,Yong Li,Paul F. Robbins,Steven A. Rosenberg +6 more
TL;DR: The modified CEA-reactive TCRs are good candidates for future gene therapy clinical trials and show the power of selected amino acid substitutions in the antigen-binding regions of the TCR to enhance desired reactivities.
References
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Journal ArticleDOI
Actively acquired tolerance of foreign cells.
TL;DR: In this article, the problem of how to make tissue homografts immunologically acceptable to hosts which would normally react against them has been studied in the context of early foetal life inoculation.
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Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques
Phil Gold,Samuel O. Freedman +1 more
TL;DR: It was shown that the tumor-specific antibodies were not directed against bacterial contaminants or against the unusually high concentrations of fibrin found in many neoplastic tissues.
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Cadherins: A Molecular Family Important in Selective Cell-Cell Adhesion
TL;DR: This paper presents a meta-analyses of cDNA transference studies on CADherin FUNCTION and discusses the role of CADherins 1N MORPHOGENESIS in this research.
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Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule.
Sarita Benchimol,Abraham Fuks,Serge Jothy,Nicole Beauchemin,Kinji Shirota,Clifford P. Stanners +5 more
TL;DR: It is demonstrated here that CEA mediates Ca2+-independent, homotypic aggregation of cultured human colon adenocarcinoma cells (LS-180) and rodent cells transfected with functional CEA cDNA and can be considered a new addition to the family of intercellular adhesion molecules.
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Use of Radiolabeled Antibodies to Carcinoembryonic Antigen for the Detection and Localization of Diverse Cancers by External Photoscanning
David M. Goldenberg,Frank H. DeLand,E. Edmund Kim,S. Bennett,F J Primus,J.R. van Nagell,N. Estes,P. DeSimone,P. Rayburn +8 more
TL;DR: To determine whether tumors containing carcinoembryonic antigen could be detected by administration of a radiolabeled, affinity-purified, goat lgG, 18 patients with a history of cancer of diverse histopathology received an average total dose of 1.0 mCi of 131l-labeled lGG.
Related Papers (5)
The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues.
Specific carcinoembryonic antigens of the human digestive system
Phil Gold,Samuel O. Freedman +1 more