Journal ArticleDOI
The cerebellar microcircuit as an adaptive filter: experimental and computational evidence
TLDR
It is concluded that many Marr–Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long- term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function.Abstract:
Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long-term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function. This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of cerebellar function, including both microcircuit processing and extra-cerebellar connectivity.read more
Citations
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Journal ArticleDOI
Consensus Paper: The Cerebellum's Role in Movement and Cognition
Leonard F. Koziol,Deborah Ely Budding,Nancy C. Andreasen,Stefano D'Arrigo,Sara Bulgheroni,Hiroshi Imamizu,Masao Ito,Mario Manto,Cherie L. Marvel,Krystal L. Parker,Giovanni Pezzulo,Narender Ramnani,Daria Riva,Jeremy D. Schmahmann,Larry Vandervert,Tadashi Yamazaki +15 more
TL;DR: The cerebellum in relation to neurocognitive development, language function, working memory, executive function, and the development of cerebellar internal control models is considered and some of the ways in which better understanding the Cerebellum's status as a “supervised learning machine” can enrich the ability to understand human function and adaptation are considered.
Journal ArticleDOI
Distributed synergistic plasticity and cerebellar learning
TL;DR: It is proposed that the different forms of plasticity in the granular layer and the molecular layer operate synergistically in a temporally and spatially distributed manner, so as to ultimately create optimal output for behaviour.
Journal ArticleDOI
Spatiotemporal firing patterns in the cerebellum
Chris I. De Zeeuw,Chris I. De Zeeuw,Freek E. Hoebeek,Laurens W. J. Bosman,Laurens W. J. Bosman,Martijn Schonewille,Laurens Witter,Sebastiaan K. E. Koekkoek +7 more
TL;DR: Expanding lines of evidence are reviewed that spatiotemporal coding occurs in the cerebellum, and that the olivocerebellar system is optimally designed to generate and employ precise patterns of complex spikes and simple spikes during the acquisition and consolidation of motor skills.
Journal ArticleDOI
A connectome of a learning and memory center in the adult Drosophila brain
Shin-ya Takemura,Yoshinori Aso,Toshihide Hige,Allan M. Wong,Zhiyuan Lu,C. Shan Xu,Patricia K. Rivlin,Harald F. Hess,Ting Zhao,Toufiq Parag,Stuart Berg,Gary B. Huang,William T. Katz,Donald J. Olbris,Stephen M. Plaza,Lowell Umayam,Roxanne Aniceto,Lei-Ann Chang,Shirley Lauchie,Omotara Ogundeyi,Christopher Ordish,Aya Shinomiya,Christopher Sigmund,Satoko Takemura,Julie Tran,Glenn C. Turner,Gerald M. Rubin,Louis K. Scheffer +27 more
TL;DR: This work reconstructed the morphologies and synaptic connections of all 983 neurons within the three functional units, or compartments, that compose the adult MB’s α lobe, using a dataset of isotropic 8 nm voxels collected by focused ion-beam milling scanning electron microscopy.
Journal ArticleDOI
Consensus Paper: Towards a Systems-Level View of Cerebellar Function: the Interplay Between Cerebellum, Basal Ganglia, and Cortex.
Daniele Caligiore,Giovanni Pezzulo,Gianluca Baldassarre,Andreea C. Bostan,Peter L. Strick,Kenji Doya,Rick C. Helmich,Michiel F. Dirkx,James C. Houk,Henrik Jörntell,Ángel Lago-Rodríguez,Joseph M. Galea,R. Chris Miall,Traian Popa,Asha Kishore,Paul F. M. J. Verschure,Riccardo Zucca,Ivan Herreros +17 more
TL;DR: There is unanimous consensus between the authors that future experimental and computational work is needed to understand the function of cerebellar-basal ganglia circuitry in both motor and non-motor functions.
References
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Book
Adaptive Signal Processing
Bernard Widrow,Samuel D. Stearns +1 more
TL;DR: This chapter discusses Adaptive Arrays and Adaptive Beamforming, as well as other Adaptive Algorithms and Structures, and discusses the Z-Transform in Adaptive Signal Processing.
Journal ArticleDOI
A Theory of Cerebellar Cortex
TL;DR: A detailed theory of cerebellar cortex is proposed whose consequence is that the cerebellum learns to perform motor skills and two forms of input—output relation are described, both consistent with the cortical theory.
Journal ArticleDOI
Internal models for motor control and trajectory planning
TL;DR: The 'minimum variance model' is another major recent advance in the computational theory of motor control, strongly suggesting that both kinematic and dynamic internal models are utilized in movement planning and control.