Journal ArticleDOI
The changing epidemiology of healthcare-associated candidemia over three decades.
Daniel J. Diekema,Sophie S Arbefeville,Linda Boyken,J. Kroeger,J. Kroeger,Michael A. Pfaller,Michael A. Pfaller +6 more
TLDR
The epidemiology of healthcare-associated candidemia (HAC) in the authors' tertiary care hospital is changing at their hospital, with continued emergence of C. glabrata, fewer cases among oncology patients, and lower in-hospital and 30-day mortality.About:
This article is published in Diagnostic Microbiology and Infectious Disease.The article was published on 2012-05-01. It has received 289 citations till now.read more
Citations
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Journal ArticleDOI
Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America
Peter G. Pappas,Carol A. Kauffman,David R. Andes,Cornelius J. Clancy,Kieren A. Marr,Luis Ostrosky-Zeichner,Annette C. Reboli,Mindy G. Schuster,Jose A. Vazquez,Thomas J. Walsh,Theoklis E. Zaoutis,Jack D. Sobel +11 more
TL;DR: IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.
Journal ArticleDOI
Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations
Barbara D. Alexander,Melissa D. Johnson,Christopher D. Pfeiffer,Cristina Jiménez-Ortigosa,Jelena Catania,Rachel Booker,Mariana Castanheira,Shawn A. Messer,David S. Perlin,Michael A. Pfaller +9 more
TL;DR: Echinocandin resistance is increasing, including among FLC-resistant isolates, and the importance of knowing the local epidemiology and resistance patterns for Candida within institutions and susceptibility testing of echinocands for C. glabrata to guide therapeutic decision making is underscored.
Journal ArticleDOI
Azole antifungal resistance in Candida albicans and emerging non-albicans Candida Species
Sarah G. Whaley,Elizabeth L. Berkow,Jeffrey M. Rybak,Andrew T. Nishimoto,Katherine S. Barker,P. David Rogers +5 more
TL;DR: This review examines azole resistance in infections caused by C. albicans as well as the emerging non-albicans Candida species C. tropicalis, C. krusei, and C. glabrata and describes the current understanding of molecular basis of azole Resistance in these fungal species.
Journal ArticleDOI
Epidemiology and risk factors for invasive candidiasis
TL;DR: The incidence of Candida al bicans was decreased in many countries, especially among patients with immunosuppressive disorders, while the incidence of species other than C. albicans was increased.
Journal ArticleDOI
Twenty Years of the SENTRY Antifungal Surveillance Program: Results for Candida Species From 1997-2016.
TL;DR: EC-R and FLU-R remain uncommon among contemporary Candida isolates; however, a slow and steady emergence of resistance to both antifungal classes was observed in C. glabrata and C. tropicalis isolates.
References
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Journal ArticleDOI
Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study
Hilmar Wisplinghoff,Tammy Bischoff,Sandra M. Tallent,Harald Seifert,Richard P. Wenzel,Michael B. Edmond +5 more
TL;DR: The proportion of nosocomial BSIs due to antibiotic-resistant organisms is increasing in US hospitals, and in neutropenic patients, infections with Candida species, enterococci, and viridans group streptococci were significantly more common.
Journal ArticleDOI
Antimicrobial-Resistant Pathogens Associated with Healthcare- Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010
Dawn M. Sievert,Philip Ricks,Jonathan R. Edwards,Amy Schneider,Jean B. Patel,Arjun Srinivasan,Alex Kallen,Brandi Limbago,Scott K. Fridkin +8 more
TL;DR: The frequency of selected antimicrobial resistance patterns among pathogens causing device-associated and procedure-associated healthcare-associated infections reported by hospitals in the National Healthcare Safety Network (NHSN) is described.
Journal ArticleDOI
Clinical practice guidelines for the management of candidiasis: 2009 update by the Infectious Diseases Society of America.
Peter G. Pappas,Carol A. Kauffman,David R. Andes,Daniel K. Benjamin,Thierry Calandra,John E. Edwards,Scott G. Filler,John F. Fisher,Bart Jan Kullberg,Luis Ostrosky-Zeichner,Annette C. Reboli,John H. Rex,Thomas J. Walsh,Jack D. Sobel +13 more
TL;DR: These updated guidelines replace the previous guidelines published in the 15 January 2004 issue of Clinical Infectious Diseases and are intended for use by health care providers who care for patients who either have or are at risk of these infections.
Journal ArticleDOI
Attributable Mortality of Nosocomial Candidemia, Revisited
Olafur Gudlaugsson,Olafur Gudlaugsson,Shane Gillespie,Kathleen Lee,Jeff Vande Berg,Jianfang Hu,Shawn A. Messer,Loreen A. Herwaldt,Loreen A. Herwaldt,Michael A. Pfaller,Michael A. Pfaller,Daniel J. Diekema,Daniel J. Diekema +12 more
TL;DR: Nosocomial candidemia is still associated with an extremely high crude and attributable mortality--much higher than that expected from underlying disease alone.
Journal ArticleDOI
Hospital-Acquired Candidemia: The Attributable Mortality and Excess Length of Stay
TL;DR: Candida bloodstream infections represented 10% of all nosocomial bloodstream infections in the period studied at the University Hospital; they are associated with a significant medical and economic burden well above that expected of the underlying diseases alone.