Epidemiology and risk factors for invasive candidiasis
TLDR
The incidence of Candida al bicans was decreased in many countries, especially among patients with immunosuppressive disorders, while the incidence of species other than C. albicans was increased.Abstract:
The number of immunosuppressive patients has increased significantly in recent years. These patients are at risk for opportunistic infections, especially fungal infections. Candidiasis is one of the most frequent fungal infections determined in these immunosuppressive patients and its epidemiology has changed over the last two decades. Recently, new antifungal agents and new therapy strategies such as antifungal prophylaxis, secondary prophylaxis, and preemptive therapy have come into use. These changes resulted in the alteration of Candida species causing invasive infections. The incidence of Candida albicans was decreased in many countries, espe- cially among patients with immunosuppressive disorders, while the incidence of species other than C. albicans was increased. In this review, incidence, risk factors, and species distribution of invasive candidiasis are discussed.read more
Citations
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Mammalian lipoxygenases and their biological relevance.
TL;DR: This review is aimed at summarizing the current knowledge on the physiological roles of different mammalian LOX-isoforms and their patho-physiological function in inflammatory, metabolic, hyperproliferative, neurodegenerative and infectious disorders.
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Candida Biofilms: Threats, Challenges, and Promising Strategies.
TL;DR: A review of the current threats and challenges when dealing with biofilms formed by Candida albicans, Candida glabrata, C. tropicalis, and C. parapsilosis can be found in this article.
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Antifungal resistance: current trends and future strategies to combat.
TL;DR: Various investigational antifungals are currently in preclinical or clinical development, including several that have the potential to overcome resistance observed against the azoles and the echinocandins, including agents that also target ergosterol and b-glucan biosynthesis.
Journal ArticleDOI
The Still Underestimated Problem of Fungal Diseases Worldwide.
TL;DR: Concerns on the occurrence of a pandemic of fungal origin in a near future have been raised and to stop forgetting and underestimating fungal diseases is mandatory.
Journal ArticleDOI
Effect of silver nanoparticles on Candida albicans biofilms: an ultrastructural study
Humberto H Lara,Dulce G. Romero-Urbina,Christopher G. Pierce,Jose L. Lopez-Ribot,M. Josefina Arellano-Jiménez,Miguel Jose-Yacaman +5 more
TL;DR: It is demonstrated that silver nanoparticles are potent inhibitors of C. albicans biofilm formation through disruption of the outer cell membrane/wall and inhibition of filamentation, which is consistent with an overall loss of structure of biofilms.
References
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Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,179 Cases from a Prospective Nationwide Surveillance Study
Hilmar Wisplinghoff,Tammy Bischoff,Sandra M. Tallent,Harald Seifert,Richard P. Wenzel,Michael B. Edmond +5 more
TL;DR: The proportion of nosocomial BSIs due to antibiotic-resistant organisms is increasing in US hospitals, and in neutropenic patients, infections with Candida species, enterococci, and viridans group streptococci were significantly more common.
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Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem
TL;DR: Improved non-culture-based diagnostics are needed to expand the potential for preemptive (or early directed) therapy and improve diagnostic, preventive, and therapeutic strategies is necessary to reduce the considerable morbidity and mortality associated with IC.
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Antimicrobial-Resistant Pathogens Associated with Healthcare- Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009-2010
Dawn M. Sievert,Philip Ricks,Jonathan R. Edwards,Amy Schneider,Jean B. Patel,Arjun Srinivasan,Alex Kallen,Brandi Limbago,Scott K. Fridkin +8 more
TL;DR: The frequency of selected antimicrobial resistance patterns among pathogens causing device-associated and procedure-associated healthcare-associated infections reported by hospitals in the National Healthcare Safety Network (NHSN) is described.
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Attributable Mortality of Nosocomial Candidemia, Revisited
Olafur Gudlaugsson,Olafur Gudlaugsson,Shane Gillespie,Kathleen Lee,Jeff Vande Berg,Jianfang Hu,Shawn A. Messer,Loreen A. Herwaldt,Loreen A. Herwaldt,Michael A. Pfaller,Michael A. Pfaller,Daniel J. Diekema,Daniel J. Diekema +12 more
TL;DR: Nosocomial candidemia is still associated with an extremely high crude and attributable mortality--much higher than that expected from underlying disease alone.
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The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study.
Livio Pagano,Morena Caira,Anna Candoni,Massimo Offidani,Luana Fianchi,Bruno Martino,Domenico Pastore,Marco Picardi,Alessandro Bonini,Anna Chierichini,Rosa Fanci,Cecilia Caramatti,Rosangela Invernizzi,Daniele Mattei,Maria Enza Mitra,Lorella Melillo,Franco Aversa,Maria Teresa Van Lint,Paolo Falcucci,Caterina Giovanna Valentini,Corrado Girmenia,Annamaria Nosari +21 more
TL;DR: Patients with hematologic malignancies are currently at higher risk of IFI caused by molds than by yeasts, and the incidence of I FI is highest among patients with acute myeloid leukemia.