The Cyclophosphamide Equivalent Dose as an Approach for Quantifying Alkylating Agent Exposure. A Report from the Childhood Cancer Survivor Study
Daniel M. Green,Vikki G. Nolan,Pamela Goodman,John Whitton,Deo Kumar Srivastava,Wendy M. Leisenring,Joseph P. Neglia,Charles A. Sklar,Sue C. Kaste,Melissa M. Hudson,Lisa Diller,Marilyn Stovall,Sarah S. Donaldson,Leslie L. Robison +13 more
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TLDR
The widely used Alkylating Agent Dose (AAD) score is derived from the drug dose distribution of the study population and thus cannot be used for comparisons across populations as each will have a unique distribution of drug doses.Abstract:
BACKGROUND
Estimation of the risk of adverse long-term outcomes such as second malignant neoplasms and infertility often requires reproducible quantification of exposures. The method for quantification should be easily utilized and valid across different study populations. The widely used Alkylating Agent Dose (AAD) score is derived from the drug dose distribution of the study population and thus cannot be used for comparisons across populations as each will have a unique distribution of drug doses.read more
Citations
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Combination chemotherapy in the treatment of advanced Hodgkin's disease.
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Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer: a report from the St Jude Lifetime Cohort Study
Daniel M. Green,Wei Liu,William H. Kutteh,Raymond W. Ke,Kyla Shelton,Charles A. Sklar,Wassim Chemaitilly,Ching-Hon Pui,James L. Klosky,Sheri L. Spunt,Sheri L. Spunt,Sheri L. Spunt,Monika L. Metzger,Monika L. Metzger,Deokumar Srivastava,Kirsten K. Ness,Leslie L. Robison,Melissa M. Hudson,Melissa M. Hudson +18 more
TL;DR: Although sperm concentration decreases with increasing CED, there was substantial overlap of CED associated with normospermia, oligospermies, and azoospermias, and these data can inform pretreatment patient counselling and use of fertility preservation services.
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Pregnancy after chemotherapy in male and female survivors of childhood cancer treated between 1970 and 1999: a report from the Childhood Cancer Survivor Study cohort
Eric J. Chow,Eric J. Chow,Kayla Stratton,Wendy M. Leisenring,Kevin C. Oeffinger,Charles A. Sklar,Sarah S. Donaldson,Jill P. Ginsberg,Lisa B. Kenney,Jennifer Levine,Leslie L. Robison,Margarett Shnorhavorian,Margarett Shnorhavorian,Marilyn Stovall,Gregory T. Armstrong,Daniel M. Green +15 more
TL;DR: Greater doses of contemporary alkylating drugs and cisplatin were associated with a decreased likelihood of siring a pregnancy in male survivors of childhood cancer.
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Temporal patterns in the risk of chronic health conditions in survivors of childhood cancer diagnosed 1970–99: a report from the Childhood Cancer Survivor Study cohort
Todd M. Gibson,Sogol Mostoufi-Moab,Kayla Stratton,Wendy M. Leisenring,Dana Barnea,Eric J. Chow,Sarah S. Donaldson,Rebecca M. Howell,Melissa M. Hudson,Anita Mahajan,Paul C. Nathan,Kirsten K. Ness,Charles A. Sklar,Emily S. Tonorezos,Christopher B. Weldon,Elizabeth Wells,Yutaka Yasui,Gregory T. Armstrong,Leslie L. Robison,Kevin C. Oeffinger +19 more
TL;DR: Results were consistent with changes in treatment as a significant mediator of the association between diagnosis decade and risk of grade 3-5 chronic conditions for astrocytoma.
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Temporal Trends in Treatment and Subsequent Neoplasm Risk Among 5-Year Survivors of Childhood Cancer, 1970-2015
Lucie M. Turcotte,Qi Liu,Yutaka Yasui,Michael Arnold,Sue Hammond,Rebecca M. Howell,Susan A. Smith,Rita E. Weathers,Tara O. Henderson,Todd M. Gibson,Wendy M. Leisenring,Gregory T. Armstrong,Leslie L. Robison,Joseph P. Neglia +13 more
TL;DR: Among survivors of childhood cancer, the risk of subsequent malignancies at 15 years after initial cancer diagnosis remained increased for those diagnosed in the 1990s, although the risk was lower compared with those diagnosis in the 1970s, and this lower risk was associated with reduction in therapeutic radiation dose.
References
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