Journal ArticleDOI
The effect of aggregation state of amphotericin-B on its interactions with cholesterol- or ergosterol-containing phosphatidylcholine monolayers
Joanna Barwicz,Pierre Tancrède +1 more
TLDR
The aim of the present work is to study the molecular basis of the interactions of AmB with these sterols contained in a DOPC film by using the monolayer technique and shows that these results provide a better understanding of the action of amphotericin B (activity/toxicity) at the membrane level.About:
This article is published in Chemistry and Physics of Lipids.The article was published on 1997-02-28. It has received 101 citations till now. The article focuses on the topics: Ergosterol & Sterol.read more
Citations
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Journal ArticleDOI
Surface active drugs: self-association and interaction with membranes and surfactants. Physicochemical and biological aspects
TL;DR: This review focuses on the self-aggregation properties of drugs, as well as on their interaction with membranes, and it is seen that drug-membrane interactions are analogous to the interactions between membranes and classical detergents.
Journal ArticleDOI
Amphotericin B Formulations and Drug Targeting
TL;DR: This review compares the different formulations of amphotericin B in terms of pharmacokinetics, toxicity and activity and discusses the possible drug targeting effect of some of these new formulations.
Journal ArticleDOI
Drug-membrane interactions: significance for medicinal chemistry.
TL;DR: The clinical significance of drug-membrane interaction studies with a special focus in the lipidic components of the membrane is reviewed, reinforcing the importance of these studies in the field of medicinal chemistry since they constitute stimulating opportunities for understanding drugs mode of action and toxic effects and cannot be overlooked during drug design and synthesis.
Journal ArticleDOI
Recent progress in the study of the interactions of amphotericin B with cholesterol and ergosterol in lipid environments.
TL;DR: Most of the reviewed studies concern monolayers at the water–gas interface, monolayer deposited on a solid substrate by use of the Langmuir–Blodgett technique, micelles, vesicles, and multi-bilayers.
Journal ArticleDOI
Gelatin coated hybrid lipid nanoparticles for oral delivery of amphotericin B.
TL;DR: The developed formulation showed significantly lesser hemolytic toxicity as compared to the free drug, Fungizone (micellar solution of AmB) and Fungisome (liposomal formulation of Amb) and blood urea nitrogen and plasma creatinine levels, indicative of nephrotoxicity, were also found to be significantly lesser.
References
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Book
The Hydrophobic Effect: Formation of Micelles and Biological Membranes
TL;DR: In this article, the authors discuss the properties of water molecules and their relationship with common soluble proteins, such as membrane proteins and membrane membrane proteins, as well as the effect of temperature on their properties.
Journal ArticleDOI
How do the polyene macrolide antibiotics affect the cellular membrane properties
TL;DR: Although pore formation is apparently involved in the toxicity of amphotericin B and nystatin, it is not the sole factor which contributes to cell death, since K+ leakage induced by these antibiotics is separate from their lethal action.
Journal ArticleDOI
Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. III. Molecular structure of the polyene antibiotic-cholesterol complexes
B. de Kruijff,Rudy A. Demel +1 more
TL;DR: Mechanisms of the polyene antibiotic induced permeability changes in membranes are proposed based on the analysis of the complexes of cholesterol, amphotericin B, nystatin, etruscomycin and pimaricin, which can be built with space-filling models.
Journal ArticleDOI
Severe Candidal Infections: Clinical Perspective, Immune Defense Mechanisms, and Current Concepts of Therapy
TL;DR: Research in patients with chronic mucocutaneous candidiasis and in-vitro manipulations have begun to elucidate normal immune defense mechanisms against Candida, including serum factors, phagocytosis, intracellular killing mechanisms, and lymphocyte function (particularly T cell).
Journal ArticleDOI
Hydrophobic barriers of lipid bilayer membranes formed by reduction of water penetration by alkyl chain unsaturation and cholesterol.
TL;DR: Results obtained in dioleoyl-PC-cholesterol membranes in the fluid phase are similar to those obtained in frozen membranes, and correlate well with permeability data for water and amino acids in the literature.
Related Papers (5)
One-sided action of amphotericin B on cholesterol-containing membranes is determined by its self-association in the medium.
Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. III. Molecular structure of the polyene antibiotic-cholesterol complexes
B. de Kruijff,Rudy A. Demel +1 more