The effect of testicular x-irradiation on spermatogenesis in man. A comparison with the mouse.
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The results suggest that, compared to the mouse, spermatogenesis in man is approximately 3.1 times more sensitive to ionizing irradiation.Abstract:
Existing data concerning the effects of x-irradiation on spermatogenesis in man were analyzed and the results were compared to published data on the mouse. Testicular x-irradiation produced a transient, but substantial, suppression of sperm counts in man, with an ED50 near 11 rad. The length of time to recovery was proportional to the irradiation dose. The ED50 for suppression of type A spermatogonia following radiation exposure in man was similar (9.7 rad), although the response curves for spermatogonia and sperm count were matogonia in the mouse was parallel to that found in man, but with an ED 50 of 30.0 rad. These results suggest that, compared to the mouse, spermatogenesis in man is approximately 3.1 times more sensitive to ionizing irradiation.read more
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ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs – Threshold Doses for Tissue Reactions in a Radiation Protection Context
F A Stewart,A V Akleyev,Martin Hauer-Jensen,Jolyon H Hendry,N J Kleiman,Thomas J. MacVittie,B M Aleman,Angela B. Edgar,K Mabuchi,C R Muirhead,Roy E. Shore,William Wallace +11 more
TL;DR: Estimates of ‘practical’ threshold doses for tissue injury defined at the level of 1% incidence are provided and it appears that the rate of dose delivery does not modify the low incidence for reactions manifesting very late after low total doses, particularly for cataracts and circulatory disease.
ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs -- threshold doses for tissue reactions in a radiation protection context
C. H. Clement,F. A. Stewart +1 more
TL;DR: In this paper, the authors present a statement on the early and late effects of ionising radiation in normal tumor and kidney responses to irradiation, as well as some modifications of normal tumor response.
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Effects of chemotherapy and radiotherapy on spermatogenesis in humans.
TL;DR: Most of the newer biologic targeted therapies seem to have only modest effects, mostly on the endocrine aspects of the male reproductive system; however, their effects when used in combination with cytotoxic agents have not been well studied.
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Germ cell transfer into rat, bovine, monkey and human testes
TL;DR: The application of this technique is the first successful attempt of a germ cell transfer in a primate and Ultrasound-guided intratesticular rete testis injection was the best and least invasive injection technique with maximal infusion efficiency for larger testes.
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Spermatogonial stem cells and spermatogenesis in mice, monkeys and men.
Adetunji P. Fayomi,Kyle E. Orwig +1 more
TL;DR: An overview of stem, progenitor and differentiating sperMatogonia that support spermatogenesis is provided; identifying parallels between rodents and primates where they exist as well as features unique to higher primates.
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