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ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs -- threshold doses for tissue reactions in a radiation protection context
C. H. Clement,F. A. Stewart +1 more
TLDR
In this paper, the authors present a statement on the early and late effects of ionising radiation in normal tumor and kidney responses to irradiation, as well as some modifications of normal tumor response.Abstract:
GUEST EDITORIAL PART I: ICRP STATEMENT ON TISSUE REACTIONS PART II: EARLY AND LATE EFFECTS OF RADIATION IN NORMAL TISSUES AND ORGANS - THRESHOLD DOSES FOR TISSUE REACTIONS IN A RADIATION PROTECTION CONTEXT ABSTRACT PREFACE EXECUTIVE SUMMARY GLOSSARY 1. INTRODUCTION 1.1. Purpose of report 1.2. Definition and nature of tissue reactions to ionising radiation 1.3. General principles of radiation effects in cells and tissues 1.4. References 2. RESPONSE OF TISSUES AND ORGANS TO RADIATION 2.1. Haematopoietic and immune systems 2.2. Digestive system 2.3. Reproductive system 2.4. Skin 2.5. Cardiovascular and cerebrovascular systems 2.6. Eye 2.7. Respiratory system 2.8. Urinary tract 2.9. Musculoskeletal system 2.10. Endocrine system 2.11. Nervous system 2.12. References 3. MODIFIERS OF NORMAL TISSUE RESPONSE 3.1. Terminology 3.2. Mechanisms of action 3.3. Influence of modifiers on radiation response in tissue 3.4. References 4. THRESHOLD DOSES IN RELATION TO RADIOSENSITIVITY OF ORGANS AND TISSUES 4.1. Introduction 4.2. Haematopoietic and immune systems 4.3. Digestive system 4.4. Reproductive system 4.5. Skin 4.6. Cardiovascular and cerebrovascular systems 4.7. Eye 4.8. Respiratory system 4.9. Urinary tract 4.10. Musculoskeletal system 4.11. Endocrine system 4.12. Nervous system 4.13. Conclusions 4.14. References ANNEX A. SUMMARY OF STUDIES OF EXPOSURE AND OPACITIES OR CATARACTSread more
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Multiphase CT Angiography: A New Tool for the Imaging Triage of Patients with Acute Ischemic Stroke
Bijoy K Menon,Christopher D d'Esterre,Emmad Qazi,Mohammed A. Almekhlafi,Leszek Hahn,Andrew M. Demchuk,Mayank Goyal +6 more
TL;DR: Multiphase CT angiography is a reliable tool for imaging selection in patients with acute ischemic stroke and its interrater reliability and ability to help determine clinical outcome are demonstrated.
Journal ArticleDOI
The appropriate and justified use of medical radiation in cardiovascular imaging: a position document of the ESC Associations of Cardiovascular Imaging, Percutaneous Cardiovascular Interventions and Electrophysiology
Eugenio Picano,Eliseo Vano,Eliseo Vano,Madan M. Rehani,Alberto Cuocolo,Lluís Mont,Vicente Bodi,Olivier Bar,Carlo Maccia,Luc Pierard,Rosa Sicari,Sven Plein,Heiko Mahrholdt,Patrizio Lancellotti,Juhani Knuuti,Hein Heidbuchel,Carlo Di Mario,Luigi P. Badano +17 more
TL;DR: A European perspective on the best way to play an active role in implementing into clinical practice the key principle of radiation protection that: 'each patient should get the right imaging exam, at the right time, with the right radiation dose'.
Journal ArticleDOI
Practical ways to reduce radiation dose for patients and staff during device implantations and electrophysiological procedures
Hein Heidbuchel,Fred H.M. Wittkampf,Eliseo Vano,Sabine Ernst,Richard J. Schilling,Eugenio Picano,Lluís Mont,Pierre Jaïs,Joseph de Bono,Christopher Piorkowski,EB Saad,Francisco Femenía +11 more
TL;DR: This position paper wants to offer some very practical advice on how to reduce exposure to patients and staff, and describes how customization of the X-ray system, workflow adaptations, and shielding measures can be implemented in the cath lab.
Journal ArticleDOI
Space radiation risks to the central nervous system
TL;DR: Recent space radiobiology studies of CNS effects from particle accelerators simulating space radiation using experimental models are summarized, and a critical assessment of their relevance relative to doses and dose-rates to be incurred on a Mars mission is made.
Journal ArticleDOI
Non-targeted effects of ionising radiation—Implications for low dose risk
Munira Kadhim,Sisko Salomaa,Eric G. Wright,Guido Hildebrandt,O.V. Belyakov,Kevin M. Prise,Mark P. Little +6 more
TL;DR: The evidence for non-targeted effects is critically examined, apparently contradictory results are discussed and implications for low-dose radiation health effects are considered.
References
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Inflammation in atherosclerosis
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Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
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TL;DR: Tastuzumab combined with paclitaxel after doxorubicin and cyclophosphamide improves outcomes among women with surgically removed HER2-positive breast cancer.
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Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
Martine Piccart-Gebhart,Marion Procter,Brian Leyland-Jones,Aron Goldhirsch,Michael Untch,Ian E. Smith,Luca Gianni,José Baselga,Richard Bell,Christian Jackisch,David Cameron,Mitch Dowsett,Carlos H. Barrios,Günther G. Steger,Chiun-Shen Huang,Martin Andersson,Moshe Inbar,Mikhail Lichinitser,István Láng,U. Nitz,Hiroji Iwata,C Thomssen,Caroline Lohrisch,Thomas M. Suter,Josef Rüschoff,Tamás Süto ý,Victoria Greatorex,Carol Ward,Eleanor McFadden,M. Stella Dolci,Richard D. Gelber +30 more
TL;DR: One year of treatment with trastuzumab after adjuvant chemotherapy significantly improves disease-free survival among women with HER2-positive breast cancer.