Journal ArticleDOI
The effects of buthionine sulphoximine (BSO) on glutathione depletion and xenobiotic biotransformation
Roger Drew,John O. Miners +1 more
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TLDR
Since BSO does not affect cytochrome P-450 or conjugating enzyme activity, its use as a specific depletor of tissue GSH in the investigation of mechanisms of xenobiotic-induced toxicities is preferable to the standard GSH-depleting agents as these have other enzyme effects.About:
This article is published in Biochemical Pharmacology.The article was published on 1984-10-01. It has received 233 citations till now. The article focuses on the topics: Buthionine sulfoximine & Glutathione.read more
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Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy.
TL;DR: Therapeutic approaches are proposed in which normal cells may be selectively protected against toxic antitumor agents and radiation by cysteine- and glutathione-delivery compounds.
Journal ArticleDOI
Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches.
TL;DR: An overview is presented on the molecular aspects of toxicity due to paracetamol (acetaminophen) and structural analogues, with emphasis on four main topics, that is, bioactivation, detoxication, chemoprevention, and chemoprotection.
Journal ArticleDOI
Engineering nanomedicine for glutathione depletion-augmented cancer therapy
TL;DR: The most recent progress in engineering nanomedicine for GSH depletion-enhanced cancer therapies, by simultaneously delivering GSH-depleting agents and therapeutic components, is summarized.
Journal Article
Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: studies with N-acetyl-D-cysteine in mice.
George B. Corcoran,B K Wong +1 more
TL;DR: Oral coadministration of N-acetyl-D-cysteine failed in preventing the elevation of serum alanine aminotransferase activity, in decreasing hepatocellular necrosis, in interdicting covalent binding of the toxic metabolite to hepato cellular proteins and in prevents the depletion of liver glutathione caused by 500 mg/kg of acetaminophen.
Journal ArticleDOI
Gene expression profiling reveals a signaling role of glutathione in redox regulation
Maddalena Fratelli,Leslie O. Goodwin,Ulf Andersson Ørom,Sarah Lombardi,Rossella Tonelli,Manuela Mengozzi,Pietro Ghezzi +6 more
TL;DR: This work demonstrates that GSH, in addition to its antioxidant and protective function against oxidative stress, has a specific signaling role in redox regulation.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
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The colorimetric estimation of formaldehyde by means of the Hantzsch reaction
TL;DR: A chronology of key events leading up to and including the birth of Bonnichsen, R. K. & Bonner, J. (1952).
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Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).
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