Journal ArticleDOI
The effects of smoking on fracture healing
Reads0
Chats0
TLDR
Cessation of the habit perioperatively is routinely advised to improve outcomes for patients, and some of the consequences of tobacco smoking in fracture healing are described.Abstract:
Tobacco smoking is the single most avoidable cause of premature death worldwide. In fracture healing, it has been found to be a contributory factor to delayed union, and smokers are significantly disadvantaged, as healing times are often prolonged. The orthopaedic surgeon is likely to be knowledgeable about the detrimental effects of smoking on healing bones, as the problem has been known for some time. Smoking adversely affects bone mineral density, lumbar disc degeneration, the incidences of hip fractures and the dynamics of bone and wound healing. Clinical trials and demographic studies have been more widespread than biochemical analyses, and have reported poor prognosis for fracture patients who smoke. Scientific research has elucidated some of the negative impacts of tobacco use and investigations involving several animal models in cellular and humoral analyses have shown damage caused by various toxicological processes. Cessation of the habit perioperatively, therefore, is routinely advised to improve outcomes for patients. The current review describes some of the consequences of tobacco smoking in fracture healing.read more
Citations
More filters
Journal ArticleDOI
Cigarette smoking increases complications following fracture: a systematic review
TL;DR: Smoking significantly increased the risk of nonunion of fractures overall, tibial fractures, and open fractures and trends toward more superficial and deep infections of postoperative or traumatic wounds in smokers were noted.
Journal ArticleDOI
Risk factors for long bone fracture non-union: a stratification approach based on the level of the existing scientific evidence
TL;DR: Clinicians should take in to account these findings when managing patients with long bone fractures, particularly the femur and tibia in order to minimise the risk of non-union.
Journal ArticleDOI
The effect of smoking on bone healing: A systematic review
TL;DR: Smoking has a negative effect on bone healing, in terms of delayed union, nonunion and more complications, as evidenced within the orthopaedic literature.
Journal ArticleDOI
Wound Healing: Part I. Basic Science
TL;DR: Understanding the physiology and pathophysiology of normal wound healing and potential impediments to its end will allow the plastic surgeon to maximize postoperative outcomes and, in some instances, avoid unnecessary surgical interventions.
Journal ArticleDOI
The Impact of Smoking on Complications After Operatively Treated Ankle Fractures—A Follow-Up Study of 906 Patients
TL;DR: It is concluded that cigarette smoking increases the risk of postoperative complications in patients operatively treated for an ankle fracture and physicians, nurses, and other healthcare professionals should strive to support patients to stop smoking while still under acute treatment.
References
More filters
Journal ArticleDOI
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.
Stephan Frank,Brigitte Gaume,Elke S. Bergmann-Leitner,Wolfgang W. Leitner,Everett G. Robert,Frédéric Catez,Carolyn L. Smith,Richard J. Youle +7 more
TL;DR: In healthy cells, fusion and fission events participate in regulating mitochondrial morphology and inhibition of Drp1 blocks cell death, implicating mitochondrial fission as an important step in apoptosis.
Journal ArticleDOI
The myofibroblast in wound healing and fibrocontractive diseases.
TL;DR: The demonstration that fibroblastic cells acquire contractile features during the healing of an open wound, thus modulating into myofibroblasts, has open a new perspective in the understanding of mechanisms leading to wound closure and fibrocontractive diseases.
Journal ArticleDOI
Metabolism and Disposition Kinetics of Nicotine
TL;DR: Current knowledge about the metabolism and disposition kinetics of nicotine, some other naturally occurring tobacco alkaloids, and nicotine analogs that are under development as potential therapeutic agents are reviewed.
Journal ArticleDOI
Cardiovascular Effects of Secondhand Smoke Nearly as Large as Smoking
TL;DR: The effects of secondhand smoke are substantial and rapid, explaining the relatively large risks that have been reported in epidemiological studies.
Journal ArticleDOI
The changing cigarette, 1950-1995
Dietrich Hoffmann,Ilse Hoffmann +1 more
TL;DR: From a public health perspective, nicotine in the smoke needs to be lowered to a level at which there is no induction of dependence on tobacco, and further needs for reducing the toxicity and carcinogenicity of cigarette smoke are discussed.
Related Papers (5)
Impact of smoking on fracture healing and risk of complications in limb-threatening open tibia fractures.
Renan C. Castillo,Michael J. Bosse,Ellen J. MacKenzie,Brendan M. Patterson,Andrew R. Burgess,Alan L. Jones,James F. Kellam,Mark P. McAndrew,Melissa L. McCarthy,Charles A. Rohde,Roy Sanders,Marc F. Swiontkowski,Lawrence X. Webb,Julie Agel,Jennifer Avery,Denise Bailey,Wendall Bryan,Debbie Bullard,Carla Carpenter,Elizabeth Chaparro,Kate Corbin,Denise Darnell,Stephaine Dickason,Thomas DiPasquale,Betty Harkin,Michael Harrington,Dolfi Herscovici,Amy Holdren,Linda Howard,Sarah Hutchings,Marie Johnson,Melissa Jurewicz,Donna Lampke,Karen Lee,Marianne Mars,Maxine Mendoza-Welch,J. Wayne Meredith,Nan Morris,Karen Murdock,Andrew N. Pollak,Pat Radey,Sandy Shelton,Sherry Simpson,Steven Sims,D. K. Smith,Adam J. Starr,Celia Weigman,John H. Wilber,Stephanie Williams,Philip R Wolinsky,Mary Woodman,Michelle Zimmerman +51 more