The FcgammaRIIa His131Arg polymorphism and its association with myocardial infarction.
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TLDR
A case–control study to investigate whether the FccRIIa G507A genotype contributes to risk of arterial thrombosis as manifested by myocardial infarction (MI), and the contribution of the polymorphism to clinical manifestations of certain hematological and autoimmune diseases.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2004-06-01 and is currently open access. It has received 6 citations till now.read more
Citations
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Journal ArticleDOI
Fcγ receptors and ligands and cardiovascular disease.
Keiji Tanigaki,Nathan C. Sundgren,Amit Khera,Wanpen Vongpatanasin,Chieko Mineo,Philip W. Shaul +5 more
TL;DR: Further knowledge of the vascular biology of Fc&ggr;R and their ligands will potentially enhance the understanding of cardiovascular disorders, particularly in patients whose greater predisposition for disease is not explained by traditional risk factors, such as individuals with autoimmune disorders.
Journal ArticleDOI
Impact of C-reactive protein on osteo-/chondrogenic transdifferentiation and calcification of vascular smooth muscle cells.
Laura A Henze,Trang T.D. Luong,Trang T.D. Luong,Beate Boehme,Jaber Masyout,Markus P. Schneider,Sebastian Brachs,Florian Lang,Burkert Pieske,Andreas Pasch,Kai-Uwe Eckardt,Jakob Voelkl,Ioana Alesutan +12 more
TL;DR: Vascular CRP expression was increased in the klotho-hypomorphic mouse model of aging as well as in HAoSMCs during calcifying conditions and augments osteo-/chondrogenic transdifferentiation of vascular smooth muscle cells through mechanisms involving FCGR2A-dependent induction of oxidative stress.
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The association between a common FCGR2A polymorphism and C-reactive protein and coronary artery disease revisited.
Christos Kroupis,Maria Theodorou,Antigoni Chaidaroglou,Maria Dalamaga,Samantha C. Oliveira,Dennis V. Cokkinos,Dimitrios Degiannis,Athanassios Manginas +7 more
TL;DR: With an accurate genotyping method, the RR genotype was correlated with atherothrombotic CAD events and the inverse correlation found between CRP levels and genotype supports the in vitro data of RR cells binding CRP stronger than HH.
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Early atherosclerosis and IgG2 to bacteria are associated with FcγRIIa genotype in non-smokers
TL;DR: This work has shown that human FcγRIIa receptor (CD32) plays a crucial role in the phagocytosis of IgG2 ICs and a functional point mutation 131His/Arg diminishes IgG 2 binding to the receptor.
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The Role of Fcγ Receptors in Myocardial Diseases and Atherosclerosis
Chiharu Kishimoto,Zuyi Yuan +1 more
TL;DR: This review summarizes recent significant progress addressing the various roles of FcγRs in the disease pathogenesis which comes from the studies of F cγRs deficient animal models, clinical investigations and in vitro molecular and cellular studies, and suggests FcαγRs as a potential therapeutic target for the diseases.
References
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Journal Article
A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding.
TL;DR: In this article, a hybrid Fc gamma RIIa molecules were constructed to determine the epitope for mAb 41H16 and the binding domain for mIgG1 and hIg2 complexes.
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Molecular basis for a polymorphism of human Fc gamma receptor II (CD32).
TL;DR: Data showing the presence of an alternatively spliced mRNA detected by using polymerase chain reaction (PCR) might suggest the existence of a soluble form of the human Fc gamma RII, in addition to the membrane- bound forms.
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Variant Genotypes of the Low-Affinity Fcγ Receptors in Two Control Populations and a Review of Low-Affinity Fcγ Receptor Polymorphisms in Control and Disease Populations
Thomas Lehrnbecher,Charles B. Foster,Shaoxian Zhu,Susan F. Leitman,Lynn R. Goldin,Konrad Huppi,Stephen J. Chanock +6 more
TL;DR: Data is presented that should serve as the foundation for the interpretation of association studies involving multiple variant alleles of the low-affinity FcgammaR.
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Heparin-Induced Thrombocytopenia: New Insights Into the Impact of the FcγRIIa-R-H131 Polymorphism
Lena E. Carlsson,Sentot Santoso,Gudrun Baurichter,Hartmut Kroll,Stephanie Papenberg,Petra Eichler,Nomdo A.C. Westerdaal,Volker Kiefel,Jan G. J. van de Winkel,Andreas Greinacher +9 more
TL;DR: It is speculated that the reduced clearance of immune complexes in patients with the FcgammaRIIa-R/R131 allotype causes prolonged activation of endothelial cells and platelets, thus increasing the risk for thrombotic complications.
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Physical proximity and functional interplay of the glycoprotein Ib-IX-V complex and the Fc receptor FcgammaRIIA on the platelet plasma membrane.
TL;DR: Results indicate that GP Ibα and FcγRIIA are co-localized on the platelet membrane and that this association is not random.