Journal ArticleDOI
The genetics of six neurotic disorders: a twin study.
TLDR
It is concluded that while there is a genetic contribution to the predisposing trait, and therefore to the intermittent appearance of symptoms, this contribution is obscured by the grouping of symptoms into diagnoses and by the help seeking which is a prerequisite to clinical diagnosis.About:
This article is published in Journal of Affective Disorders.The article was published on 1990-05-01. It has received 227 citations till now. The article focuses on the topics: Twin study & Neuroticism.read more
Citations
More filters
Journal ArticleDOI
Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
Klaus-Peter Lesch,D. Bengel,Armin Heils,Sue Z. Sabol,Benjamin D. Greenberg,Susanne Petri,Jonathan Benjamin,Clemens R. Müller,Dean H. Hamer,Dennis L. Murphy +9 more
TL;DR: The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5HTT expression and 5HT uptake in lymphoblasts as discussed by the authors, which is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs.
Journal ArticleDOI
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
TL;DR: A meta-analysis of relevant data from primary studies of the genetic epidemiology of major depression suggested that familial aggregation was due to additive genetic effects, with a minimal contribution of environmental effects common to siblings and substantial individual-specific environmental effects/measurement error.
Journal ArticleDOI
A review and meta-analysis of the genetic epidemiology of anxiety disorders.
TL;DR: Meta-analyses of data from family and twin studies of panic disorder, generalized anxiety disorder, phobias, and obsessive-compulsive disorder revealed significant familial aggregation, underscoring the importance of identifying putative environmental risk factors that predispose individuals to anxiety.
Journal ArticleDOI
Unraveling the mysteries of anxiety and its disorders from the perspective of emotion theory.
TL;DR: In this paper, a model specifies an integrated set of triple vulnerabilities: a generalized biological (heritable) vulnerability, a generalized psychological vulnerability based on early experiences in developing a sense of control over salient events, and a more specific psychological vulnerability in which one learns to focus anxiety on specific objects or situations.
Journal ArticleDOI
A family study of obsessive-compulsive disorder.
Gerald Nestadt,Jack Samuels,Mark A. Riddle,O. Joseph Bienvenu,Kung Yee Liang,Michele C. LaBuda,John T. Walkup,Marco A. Grados,Rudolf Hoehn-Saric +8 more
TL;DR: Obsessive-compulsive disorder is a familial disorder and age at onset of OCD is valuable in characterizing a familial subtype, more specific to the phenotype than are compulsions.
References
More filters
Book
Statistical methods for rates and proportions
TL;DR: In this paper, the basic theory of Maximum Likelihood Estimation (MLE) is used to detect a difference between two different proportions of a given proportion in a single proportion.
Journal ArticleDOI
Statistical Methods for Rates and Proportions
R. L. Plackett,Joseph L. Fleiss +1 more
Journal ArticleDOI
Lifetime Prevalence of Specific Psychiatric Disorders in Three Sites
Lee N. Robins,John E. Helzer,Myrna M. Weissman,Helen Orvaschel,Ernest M. Gruenberg,Jack D. Burke,Darrel A. Regier +6 more
TL;DR: Lifetime rates are presented for 15 DSM-III psychiatric diagnoses evaluated in three large household samples on the basis of lay interviewers' use of the Diagnostic Interview Schedule.
Journal ArticleDOI
Genetic Factors in Anxiety Disorders
TL;DR: Investigating genetic factors in the determination of anxiety disorders in a study of adult same-sexed twins found genetic factors appear to influence the development of the other anxiety disorders, especially panic disorder and agoraphobia with panic attacks.
Journal ArticleDOI
Symptoms of Anxiety and Symptoms of Depression: Same Genes, Different Environments?
TL;DR: The results, which are replicated across sexes, suggest that the separable anxiety and depression symptom clusters in the general population are largely the result of environmental factors.