The incidence and magnitude of fibrinolytic activation in trauma patients.
Imran Raza,Ross Davenport,C Rourke,Sean Platton,Joanna Manson,C. Spoors,S Khan,Henry D. De’Ath,Shubha Allard,Daniel P. Hart,K. J. Pasi,Beverley J. Hunt,Simon J. Stanworth,Peter MacCallum,Karim Brohi +14 more
TLDR
Paradigms in clinical trials suggest a much broader indication for antifibrinolytics than previously thought, and suggest the need for additional drugs to treat trauma is much greater than currently thought.About:
This article is published in Journal of Thrombosis and Haemostasis.The article was published on 2013-02-01 and is currently open access. It has received 413 citations till now. The article focuses on the topics: Hyperfibrinolysis & Thromboelastometry.read more
Citations
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The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition
Rolf Rossaint,Bertil Bouillon,Vladimir Cerny,Timothy J Coats,Jacques Duranteau,Enrique Fernández-Mondéjar,Daniela Filipescu,Beverley J. Hunt,Radko Komadina,Giuseppe Nardi,Edmund Neugebauer,Yves Ozier,Louis Riddez,Arthur Schultz,Jean Louis Vincent,Donat R. Spahn +15 more
TL;DR: The guideline now recommends that patients be transferred directly to an appropriate trauma treatment centre and encourages use of a restricted volume replacement strategy during initial resuscitation, and may also serve as a basis for local implementation.
Journal ArticleDOI
Goal-directed Hemostatic Resuscitation of Trauma-induced Coagulopathy: A Pragmatic Randomized Clinical Trial Comparing a Viscoelastic Assay to Conventional Coagulation Assays.
Eduardo Gonzalez,Ernest E. Moore,Hunter B. Moore,Michael P. Chapman,Theresa L. Chin,Arsen Ghasabyan,Max V. Wohlauer,Carlton C. Barnett,Denis D. Bensard,Walter L. Biffl,Clay Cothren Burlew,Jeffrey L. Johnson,Fredric M. Pieracci,Gregory J. Jurkovich,Anirban Banerjee,Christopher C. Silliman,Angela Sauaia,Angela Sauaia,Angela Sauaia +18 more
TL;DR: Utilization of a goal-directed, TEG-guided MTP to resuscitate severely injured patients improves survival compared with an MTP guided by CCA and utilizes less plasma and platelet transfusions during the early phase of resuscitation.
Journal ArticleDOI
TEG and ROTEM: Technology and clinical applications
David Whiting,James A. DiNardo +1 more
TL;DR: Rotational thromboelastometry (ROTEM) and TEG analysis is being incorporated in vertical algorithms to diagnose and treat bleeding in high‐risk populations such as those undergoing cardiac surgery or suffering from blunt trauma.
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Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy.
Hunter B. Moore,Ernest E. Moore,Eduardo Gonzalez,Michael P. Chapman,Theresa L. Chin,Christopher C. Silliman,Anirban Banerjee,Angela Sauaia +7 more
TL;DR: A U-shaped distribution of death related to the fibrinolysis system in response to major trauma is identified, with a nadir in mortality, with level of fibrinelysis after 30 minutes between 0.81% and 2.9%.
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Disseminated intravascular coagulation
TL;DR: An updated overview of the pathophysiology, diagnosis and management of Disseminated intravascular coagulation is provided and the future directions of basic and clinical research in this field are discussed.
References
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The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care
TL;DR: Results of this investigation indicate that the Injury Severity Score represents an important step in solving the problem of summarizing injury severity, especially in patients with multiple trauma.
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Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial
TL;DR: Tranexamic acid safely reduced the risk of death in bleeding trauma patients in this study, and should be considered for use in bleed trauma patients.
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Epidemiology of trauma deaths: a reassessment
Angela Sauaia,Frederick A. Moore,Ernest E. Moore,Kathe S. Moser,Regina Brennan,Robert A. Read,Peter T. Pons +6 more
TL;DR: There was an improved access to the medical system, greater proportion of late deaths due to brain injury and lack of the classic trimodal distribution, in the Denver City and County trauma system during 1992.
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Acute traumatic coagulopathy.
TL;DR: There is a common and clinically important acute traumatic coagulopathy that is not related to fluid administration that is related to mortality and a coagulation screen is an important early test in severely injured patients.
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The global burden of injuries.
TL;DR: Public health officials must gain a better understanding of the magnitude and characteristics of the problem, contribute to the development and evaluation of injury prevention programs, and develop the best possible prehospital and hospital care and rehabilitation for injured persons.