Open AccessJournal Article
The incidence and prognosis of central nervous system disease in systemic lupus erythematosus.
TLDR
Most CNS events were self-limited, reversible and not associated with poor outcome unless accompanied by multisystem disease activity, and therapy with corticosteroids did not appear to offer substantial benefit.Abstract:
In a review of our experience with systemic lupus erythematosus (SLE) since 1975, we found 48 of 266 patients with major central nervous system (CNS) manifestations for which a non-SLE explanation could not be identified. Eleven patients developed more than one type of CNS event. The commonest symptom was seizure (18 patients), followed by brainstem dysfunction (12 patients), psychosis (11 patients), organic brain syndrome (11 patients) and stroke (7 patients). In 19% of cases, CNS manifestations were accompanied by a flare of multisystem SLE disease activity. Anticonvulsants were able to be discontinued safely in the majority of patients with seizures. Most CNS events were self-limited, reversible and not associated with poor outcome unless accompanied by multisystem disease activity. Therapy with corticosteroids did not appear to offer substantial benefit.read more
Citations
More filters
Journal ArticleDOI
The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes
Matthew H. Liang,Michael Corzillius,Sang Cheol Bae,Robert A. Lew,Paul R. Fortin,Caroline Gordon,David A. Isenberg,Graciela S. Alarcón,Karin V. Straaton,Judah A. Denburg,Susan D. Denburg,John M. Esdaile,Bonnie I. Glanz,Elizabeth W. Karlson,Shahram Khoshbin,Malcolm P. Rogers,Peter H. Schur,John G. Hanly,Elizabeth Kozora,Sterling G. West,Robert G. Lahita,Michael D. Lockshin,Joseph M. McCune,Patricia M. Moore,Michelle Petri,W. Neal Roberts,Jorge Sánchez-Guerrero,Martin Veilleux,Robin L. Brey,Wayne D. Cornblath,Christopher M. Filley,John D. Fisk,Pontus Harten,Elaine M. Hay,Grant L. Iverson,Steven R. Levine,Elizabeth Waterhouse,Daniel J. Wallace,John B. Winer +38 more
TL;DR: The American College of Rheumatology Nomenclature for NPSLE provides case definitions for 19 neuropsychiatric syndromes seen in SLE, with reporting standards and recommendations for laboratory and imaging tests.
Journal ArticleDOI
Traditional Framingham risk factors fail to fully account for accelerated atherosclerosis in systemic lupus erythematosus.
John M. Esdaile,Michal Abrahamowicz,Tamara Grodzicky,Yin Li,Constantina Panaritis,Roxane du Berger,Robert Côté,Steven A. Grover,Paul R. Fortin,Ann E. Clarke,Jean-Luc Senécal +10 more
TL;DR: There is a substantial and statistically significant increase in CHD and stroke in SLE that cannot be fully explained by traditional Framingham risk factors alone.
Journal ArticleDOI
Premature morbidity from cardiovascular and cerebrovascular diseases in women with systemic lupus erythematosus.
TL;DR: Young women with SLE are at substantially increased risk of AMI, CHF, and CVA, and the relative odds of these conditions decrease with age among women withSLE.
Journal ArticleDOI
The prevalence of neuropsychiatric syndromes in systemic lupus erythematosus
TL;DR: According to the ACR nomenclature, there is a high prevalence of NP manifestations in a population-based sample of patients with SLE and most NP syndromes were classified as minor; if they were excluded, the 46% prevalence of NPSLE would be slightly less than estimated in previous studies.
Journal ArticleDOI
Systemic lupus erythematosus.
TL;DR: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease of fluctuating severity in which the production of autoantibodies to cellular constituents, particularly DNA, is associated with a wide variety of systemic manifestations.
Related Papers (5)
The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes
Matthew H. Liang,Michael Corzillius,Sang Cheol Bae,Robert A. Lew,Paul R. Fortin,Caroline Gordon,David A. Isenberg,Graciela S. Alarcón,Karin V. Straaton,Judah A. Denburg,Susan D. Denburg,John M. Esdaile,Bonnie I. Glanz,Elizabeth W. Karlson,Shahram Khoshbin,Malcolm P. Rogers,Peter H. Schur,John G. Hanly,Elizabeth Kozora,Sterling G. West,Robert G. Lahita,Michael D. Lockshin,Joseph M. McCune,Patricia M. Moore,Michelle Petri,W. Neal Roberts,Jorge Sánchez-Guerrero,Martin Veilleux,Robin L. Brey,Wayne D. Cornblath,Christopher M. Filley,John D. Fisk,Pontus Harten,Elaine M. Hay,Grant L. Iverson,Steven R. Levine,Elizabeth Waterhouse,Daniel J. Wallace,John B. Winer +38 more