Journal ArticleDOI
The involvement of guanine nucleotide binding proteins in the pathogenesis and treatment of affective disorders
Sofia Avissar,Gabriel Schreiber +1 more
TLDR
The results suggest that attenuation of beta-adrenergic receptor-coupled Gs protein function, which is common to both antidepressant and antibipolar treatments, may be the mechanism underlying their antidepressant therapeutic efficacy.About:
This article is published in Biological Psychiatry.The article was published on 1992-03-01. It has received 102 citations till now. The article focuses on the topics: G protein & Signal transduction.read more
Citations
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Journal ArticleDOI
Anti-bipolar therapy: mechanism of action of lithium.
TL;DR: This review introduces the concepts that multiple actions of lithium are critical for its therapeutic effect, and that these complex effects stabilize neuronal activities, support neural plasticity, and provide neuroprotection.
Journal ArticleDOI
Lithium and brain signal transduction systems
Richard S. Jope,Mary B. Williams +1 more
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Cerebral cortex Gs alpha protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder.
L.T. Young,Peter P. Li,Stephen J. Kish,Kin Po Siu,A. Kamble,Oleh Hornykiewicz,Oleh Hornykiewicz,Jerry J. Warsh +7 more
TL;DR: The present study confirms and extends earlier findings and supports the notion that increased Gsα levels and possibly Gs α‐adenylyl cyclase‐mediated signal transduction are relevant to the pathophysiology of bipolar affective disorder.
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Antidepressants: past, present and future.
Jerzy Vetulani,Irena Nalepa +1 more
TL;DR: It is now assumed that several distinct receptor mechanisms' trigger different but converging intracellular signal cascades that activate transcription factors, which, in turn, promote the expression of genes encoding for proteins, that play a crucial role in restoring of neuronal functions involved in mood regulation.
Journal Article
Overview of the Mechanism of Action of Lithium in the Brain: Fifty-Year Update
Robert H. Lenox,Chang-Gyu Hahn +1 more
TL;DR: Chronic lithium regulates transcriptional factors, which in turn may modulate the expression of a variety of genes that compensate for aberrant signaling associated with the pathophysiology of bipolar disorder.
References
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Journal ArticleDOI
G proteins: transducers of receptor-generated signals
TL;DR: This paper presents a meta-analysis of G Protein Interactions and its Foundations, which states that G Proteins are Law-Regulated and G Protein-Effector Interactions are Nonvolatile.
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Studies and perspectives of protein kinase C
TL;DR: A novel role of this protein kinase system seems to give a logical basis for clarifying the biochemical mechanism of signal transduction, and to add a new dimension essential to the understanding of cell-to-cell communication.
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The catecholamine hypothesis of affective disorders: a review of supporting evidence
TL;DR: The "catecholamine hypothesis of affective disorders" as discussed by the authors suggests that depression is associated with an absolute or relative decrease in catecholamines, particularly norepinephrine, available at central adrenergic receptor sites.