The metabolism of acetone in rat.
TLDR
The data suggest that acetone both acts to induce a critical enzyme or enzymes and serves as a precursor for the production of 1,2-propanediol, and it is also clear that chronic acetone feeding plays a role in 2,3-butanediol production in the rat.About:
This article is published in Journal of Biological Chemistry.The article was published on 1984-01-10 and is currently open access. It has received 271 citations till now. The article focuses on the topics: Methylglyoxal pathway & Methylglyoxal.read more
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The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological life.
TL;DR: Investigation has brought new developments in the involvement of the glyoxalase in cell growth and vesicle mobilization, with increasing evidence of changes in the gly oxalase system during tumor growth and diabete mellitus, particularly relating to the development of associated clinical complications.
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Enzyme induction in the cytochrome P-450 system.
TL;DR: Article de synthese traitant de l'induction enzymatique du cytochrome P450 du rat, extension a une etude interspecifique.
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The therapeutic implications of ketone bodies: the effects of ketone bodies in pathological conditions: ketosis, ketogenic diet, redox states, insulin resistance, and mitochondrial metabolism
TL;DR: The effects of ketone body metabolism suggests that mild ketosis may offer therapeutic potential in a variety of different common and rare disease states, and current ketogenic diets are all characterized by elevations of free fatty acids, which may lead to metabolic inefficiency by activation of the PPAR system and its associated uncoupled mitochondrial uncoupling proteins.
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Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis
TL;DR: Prevention and therapy opposing the development of steatosis and its progression to more severe injury can be achieved by a multifactorial approach: control of alcohol consumption, avoidance of obesity and of excess dietary long-chain fatty acids, and replenishment of S-adenosylmethionine and PCs by using PPC.
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Role of CYP2E1 in the Hepatotoxicity of Acetaminophen
TL;DR: When cyp2e1 knockout mice were challenged with the common analgesic acetaminophen, they were found to be considerably less sensitive to its hepatotoxic effects than wild-type animals, indicating that this P-450 is the principal enzyme responsible for the metabolic conversion of the drug to its active hepatot toxic metabolite.
References
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HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS: A Biochemical and Fine Structural Study
M. N. Berry,Daniel S. Friend +1 more
TL;DR: Cytoplasmic vacuolization in a small percentage of cells and potassium loss are the only indications of cell injury detected, and the isolated cells are comparable to normal hepatic parenchymal cells in situ in appearance and function.
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Gluconeogenesis in the perfused rat liver.
TL;DR: Addition of lactate, and especially ammonium salts, increased the uptake of oxygen more than expected on the basis of the ATP requirements of the gluconeogenesis and urea synthesis.
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Synthesis of cell constituents from C2-units by a modified tricarboxylic acid cycle.
H. L. Kornberg,Hans A. Krebs +1 more