Journal ArticleDOI
The nanoscale geometry of TiO2 nanotubes influences the osteogenic differentiation of human adipose-derived stem cells by modulating H3K4 trimethylation.
Longwei Lv,Yunsong Liu,Ping Zhang,Xiao Zhang,Jianzhang Liu,Tong Chen,Penglei Su,Hongyi Li,Yongsheng Zhou +8 more
TLDR
The varied osteogenic behaviors of human adipose-derived stem cells on titanium dioxide (TiO2) nanotube arrays of different diameters are explored and the epigenetic mechanism by which nanotopography directs stem cell fate is revealed for the first time.About:
This article is published in Biomaterials.The article was published on 2015-01-01. It has received 161 citations till now. The article focuses on the topics: Cellular differentiation & Stem cell.read more
Citations
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Polydopamine-Templated Hydroxyapatite Reinforced Polycaprolactone Composite Nanofibers with Enhanced Cytocompatibility and Osteogenesis for Bone Tissue Engineering
Xiang Gao,Jinlin Song,Ping Ji,Xiaohong Zhang,Xiaoman Li,Xiao Xu,Mengke Wang,Siqi Zhang,Yi Deng,Feng Deng,Shicheng Wei +10 more
TL;DR: This study demonstrated that the developed tHA/PCL composite nanofibers with enhanced cytocompatibility and osteogenic capacity hold great potential as scaffolds for bone tissue engineering.
Journal ArticleDOI
A Review on the Electrochemically Self-organized Titania Nanotube Arrays: Synthesis, Modifications, and Biomedical Applications
TL;DR: The most promising applications reported recently in biomedical directions and modifications carried out by doping, surface modification, and thermal annealing toward improving the properties of anodically formed TiO2 nanotubes are shown.
Journal ArticleDOI
Multi-Scale Surface Treatments of Titanium Implants for Rapid Osseointegration: A Review
Qingge Wang,Peng Zhou,Shifeng Liu,Shokouh Attarilar,Robin Lok-Wang Ma,Yinsheng Zhong,Liqiang Wang +6 more
TL;DR: The advances in multi-scale surface technology of titanium implants to accelerate the osseointegration process are summarized and functionalized coatings with organic and non-organic loadings suggest good prospects for the future of modern biotechnology.
Patent
Osteogenic differentiation of mesenchymal stem cells
TL;DR: The present invention relates to a method and to the use of a method for and / or promote induce osteogenic differentiation using extracellular vesicles.
Journal ArticleDOI
Nanomaterial-based bone regeneration
Yulin Li,Changsheng Liu +1 more
TL;DR: The natural hierarchical architecture of bone and its regeneration mechanisms are elucidated, and recent progress in the development of nanomaterials which can promote bone regeneration through bone-healing mimicry (e.g., compositional, nanocrystal formation, structural, and growth factor-related mimicking) is summarized.
References
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Journal ArticleDOI
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
Matthew J. Dalby,Nikolaj Gadegaard,Rahul S. Tare,Abhay Andar,Mathis O. Riehle,Pawel Herzyk,Chris D. W. Wilkinson,Richard O.C. Oreffo +7 more
TL;DR: The use of nanoscale disorder is demonstrated to stimulate human mesenchymal stem cells (MSCs) to produce bone mineral in vitro, in the absence of osteogenic supplements, which has implications for cell therapies.
Journal ArticleDOI
Engineering substrate topography at the micro- and nanoscale to control cell function.
TL;DR: The use of in vitro synthetic cell-nanotopography interactions to control cell behavior and influence complex cellular processes, including stem-cell differentiation and tissue organization are reviewed.
Journal ArticleDOI
Stem cell fate dictated solely by altered nanotube dimension
TL;DR: Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion or a specific differentiation of hMSCs into osteoblasts by using only the geometric cues, absent of osteogenic inducing media.
Journal ArticleDOI
Nanosize and Vitality: TiO2 Nanotube Diameter Directs Cell Fate
TL;DR: Self-assembled layers of vertically oriented TiO2 nanotubes with defined diameters between 15 and 100 nm are generated and show that adhesion, spreading, growth, and differentiation of mesenchymal stem cells are critically dependent on the tube diameter.
Journal ArticleDOI
Improved bone-forming functionality on diameter-controlled TiO2 nanotube surface
Karla S. Brammer,Seunghan Oh,Christine J. Cobb,Lars Magnus Bjursten,Henri van der Heyde,Sungho Jin +5 more
TL;DR: Large diameter nanotubes, in the approximately 100 nm regime, induced extremely elongated cellular shapes, with an aspect ratio of 11:1, which resulted in substantially enhanced up-regulation of alkaline phosphatase activity, suggesting greater bone-forming ability than nanot tubes with smaller diameters.