Journal ArticleDOI
The nature of cis amine Pd(II) and antitumor cis amine Pt(II) complexes in aqueous solutions
M.C. Lim,R. Bruce Martin +1 more
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In this article, the reactionivity of cis dichloro Pt(II) amine antitumor complexes is reduced by Cl−, OH− and dihydroxy bridged dimer substituents, the formation of which is time dependent.About:
This article is published in Journal of Inorganic and Nuclear Chemistry.The article was published on 1976-01-01. It has received 163 citations till now. The article focuses on the topics: Dimer.read more
Citations
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Direct cellular responses to platinum-induced DNA damage
Yongwon Jung,Stephen J. Lippard +1 more
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DNA Cross-Linking Agents as Antitumor Drugs.
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Synthetic Methods for the Preparation of Platinum Anticancer Complexes
TL;DR: The demonstration in the 1960's that cis-diamminedichloroplatinum(II), or cisplatin, inhibits cellular division of Escherichia coli1 led to the subsequent discovery that this simple coordination compound is also an effective antitumor agent in mouse models.
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Binding of the antitumor drug cis-diamminedichloroplatinum(II) (Cisplatin) to DNA
Ann L. Pinto,Stephen J. Lippard +1 more
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New chemistry of an old molecule: cis-[Pt(NH3)2Cl2]
TL;DR: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water.
References
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Journal ArticleDOI
Studies on the antitumor activity of group VIII transition metal complexes. Part I. Platinum (II) complexes
TL;DR: A wide variety of Platinum(II) complexes have been investigated for antitumor activity against Sarcoma 180 in Swiss white female mice as mentioned in this paper, and the results showed that only neutral complexes exhibit activity while charged species are inactive and relatively nontoxic.
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Platinum coordination complexes in cancer chemotherapy
TL;DR: C cis-Dichlorodiammineplatinum (II), the most widely investigated drug, has completed Phase I clinical trials and is now in Phase II, and appears to be a broad spectrum anti-tumor drug.
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Structure and activity relationships of platinum complexes with anti-tumour activity.
TL;DR: A number of complexes of platinum(II) and platinum(IV) have been prepared, characterised and tested for their ability to cause regression of a mouse plasma cell tumour.
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Interaction of cis-dichlorodiammineplatinum (II) with DNA.
P. Horáček,J. Drobník +1 more
TL;DR: Cis-Pt(II), which is a promising antitumour agent, changes the absorption ultraviolet spectrum of calf thymus DNA; the absorption maximum is shifted from 259 to 264 nm, and hyperchromicity is observed already at room temperature.