Journal ArticleDOI
The neural basis of functional brain imaging signals.
TLDR
A firm understanding of the BOLD response will require investigation to be focussed on the neural signalling mechanisms controlling blood flow rather than on the locus of energy use.About:
This article is published in Trends in Neurosciences.The article was published on 2002-12-01. It has received 914 citations till now. The article focuses on the topics: Resting state fMRI & Functional magnetic resonance imaging.read more
Citations
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Journal ArticleDOI
Glial and neuronal control of brain blood flow.
David Attwell,Alastair M. Buchan,Serge Charpak,Martin Lauritzen,Brian A. MacVicar,Eric A. Newman +5 more
TL;DR: It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles.
Journal ArticleDOI
Neurovascular regulation in the normal brain and in Alzheimer's disease.
TL;DR: The emerging view is that cerebroVascular dysregulation is a feature not only of cerebrovascular pathologies, such as stroke, but also of neurodegenerative conditions, suchas Alzheimer's disease.
Commentary A default mode of brain function: A brief history of an evolving idea
TL;DR: The concept of a default mode of brain function arose out of a focused need to explain the appearance of activity decreases in functional neuroimaging data when the control state was passive visual fixation or eyes closed resting as discussed by the authors.
Journal ArticleDOI
A default mode of brain function: a brief history of an evolving idea.
TL;DR: This work determined that activity decreases in functional neuroimaging data did not arise from activations in the resting state, and thereby implied the existence of a default mode of brain function.
Journal ArticleDOI
Interpreting the BOLD signal.
TL;DR: The current understanding of the causal relationships between neural activity and the blood-oxygen-level-dependent (BOLD) signal is described, and how these analyses have challenged some basic assumptions that have guided neuroscience are reviewed.
References
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Journal ArticleDOI
Neurophysiological investigation of the basis of the fMRI signal
TL;DR: These findings suggest that the BOLD contrast mechanism reflects the input and intracortical processing of a given area rather than its spiking output, and that LFPs yield a better estimate of BOLD responses than the multi-unit responses.
Journal ArticleDOI
Brain magnetic resonance imaging with contrast dependent on blood oxygenation
TL;DR: In this paper, the authors demonstrate in vivo images of brain microvasculature with image contrast reflecting the blood oxygen level, which can be used to provide in vivo real-time maps of blood oxygenation in the brain under normal physiological conditions.
Brainmagnetic resonance imaging withcontrast dependent on blood oxygenation
TL;DR: It is demonstrated that in vivo images of brain microvasculature with image contrast reflecting the blood oxygen level can be used to provide in vivo real-time maps of blood oxygenation in the brain under normal physiological conditions.
Journal ArticleDOI
An Energy Budget for Signaling in the Grey Matter of the Brain
David Attwell,Simon B. Laughlin +1 more
TL;DR: The estimates of energy usage predict the use of distributed codes, with ≤15% of neurons simultaneously active, to reduce energy consumption and allow greater computing power from a fixed number of neurons.
Journal ArticleDOI
Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.
Peter T. Fox,Marcus E. Raichle +1 more
TL;DR: Dynamic, physiological regulation of CBF by a mechanism (neuronal or biochemical) dependent on neuronal firing per se, but independent of the cerebral metabolic rate of oxygen, is hypothesized.
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