Journal ArticleDOI
The organization and mutability of the forepaw and hindpaw representations in the somatosensory cortex of the neonatal rat.
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TLDR
The present study demonstrates that the primary somatosensory cortex of the rat contains a map of the entire body surface that is discernible with a routine anatomical staining technique, the succinic dehydrogenase reaction, indicating that the role of the periphery in organizing central neuronal structures during development previously demonstrated for the trigeminal system extends to the entire rat somatoensory system.Abstract:
The present study demonstrates that the primary somatosensory cortex of the rat contains a map of the entire body surface that is discernible with a routine anatomical staining technique, the succinic dehydrogenase reaction. The overall proportions of this map are relatively constant from rat to rat and very similar to those reported in previous physiological investigations (Welker: Brain Res. 26:259–275, '71, J. Comp. Neurol. 166:173–190, '76). We found 67% of the map to be related to the head of the rat, 15% to the forelimb, 14% to the trunk, and 4% to the hindlimb. Within the forelimb and indlimb representations, there is a consistent internal organization that can be related to specific peripheral structures (digits or palm pads). Further, damage to either the periphery or the nerves innervating these regions on the day of birth produces disruptions in the normal pattern, but damage on day 6 or later does not. We interpret these results as indicating that the role of the periphery in organizing central neuronal structures during development previously demonstrated for the trigeminal system extends to the entire rat somatosensory system. Comparison of the present results with physiological studies of adult cortical maps after peripheral damage suggests to us that different substrates underlie the changes reported in the adult.read more
Citations
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Specification of cerebral cortical areas
TL;DR: The radial unit model provides a framework for understanding cerebral evolution, epigenetic regulation of the parcellation of cytoarchitectonic areas, and insight into the pathogenesis of certain cortical disorders in humans.
Journal ArticleDOI
Widespread dispersion of neuronal clones across functional regions of the cerebral cortex.
TL;DR: To examine experimentally whether topographic restrictions to cell intermixing occur during formation of functional subdivisions in the rat neocortex, clonally related neocortical cells were marked by retroviral-mediated transfer of a histochemical marker gene.
Journal ArticleDOI
Potential of visual cortex to develop an array of functional units unique to somatosensory cortex
TL;DR: Findings show that different regions of the developing neocortex have similar potentials to differentiate features that distinguish neocortical areas and contribute to their unique functional organizations.
Journal ArticleDOI
Terminal arbors of axons projecting to the somatosensory cortex of the adult rat. I. The normal morphology of specific thalamocortical afferents
TL;DR: The morphology, size, and distribution of these terminal arbors support the hypothesis that the layer IV plexus of a single specific thalamocortical afferent tends to fill a vibrissae-related cluster within the somatotopic map of the rodent neocortex.
Journal ArticleDOI
The organization of neocortex in mammals: are species differences really so different?
Leah Krubitzer,Leah Krubitzer +1 more
TL;DR: It is suggested that the plan of organization that is retained is the result of homologous developmental events, and that modifications to this plan are generated by a limited set of mechanisms that might account for the sensory and behavioural diversity that is observed in extant mammals.
References
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Journal ArticleDOI
The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex. The description of a cortical field composed of discrete cytoarchitectonic units.
TL;DR: The author describes how his methods of investigation with celloidin embedded material prepared with the Golgi method and Nissl staining revealed for the first time the “barrel fields” of the mouse cerebral cortex that are activated by stimulation of the facial vibrissae (whiskers).
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Somatosensory cortical map changes following digit amputation in adult monkeys
Michael M. Merzenich,R. J. Nelson,Michael P. Stryker,Max S. Cynader,Axel Schoppmann,John M. Zook +5 more
TL;DR: The cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2–8 months after surgical amputation of digit 3, or of both digits 2 and 3.
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Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation
TL;DR: This paper found that after the median nerve was transected and ligated in adult owl and squirrel monkeys, the cortical sectors representing it within skin surface representations in Areas 3b and 1 were completely occupied by 'new' and expanded representations of surrounding skin fields.
Journal ArticleDOI
Microelectrode delineation of fine grain somatotopic organization of (SmI) cerebral neocortex in albino rat.
TL;DR: Microelectrode recording, systematic mapping, and cytoarchitectural techniques were combined in the present study to determine fine details in the patterns of somatic sensory projections from mystacial vibrissae, and other body regions, to SmI of the rat.
Journal ArticleDOI
Mapping the body representation in the SI cortex of anesthetized and awake rats
John K. Chapin,Chia-Sheng Lin +1 more
TL;DR: The cytoarchitectonic zones within the rat SI were divided into the following main categories: granular zones (GZs)–areas exhibiting koniocortical cy toarchitecture (i.e., containing dense aggregates of layer IV granule cells), perigranular zones [PGZs]–narrow strips of less granular cortex surrounding the GZs, and (3) dysgranular zones
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The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex. The description of a cortical field composed of discrete cytoarchitectonic units.
Mapping the body representation in the SI cortex of anesthetized and awake rats
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