The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume.
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This article is published in Proceedings of the National Academy of Sciences of the United States of America.The article was published on 1926-03-01 and is currently open access. It has received 1820 citations till now. The article focuses on the topics: Blood volume.read more
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Fossil skulls reveal that blood flow rate to the brain increased faster than brain volume during human evolution.
TL;DR: During 3 Myr of hominin evolution, cerebral tissue perfusion increased 1.7-fold, which indicates a 6.0-fold increase in total cerebral blood flow rate, which is probably associated with increased interneuron connectivity, synaptic activity and cognitive function, which all ultimately depend on cerebral metabolic rate.
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Blood Pressure and Retinal Microvascular Characteristics During Pregnancy Growing Up in Singapore Towards Healthy Outcomes (GUSTO) Study
Ling-Jun Li,Carol Y. Cheung,M. Kamran Ikram,Peter D. Gluckman,Michael J. Meaney,Yap Seng Chong,Kenneth Kwek,Tien Yin Wong,Seang-Mei Saw +8 more
TL;DR: In this article, the authors investigated whether maternal blood pressure during mid-pregnancy has an impact on the retinal microcirculation among pregnant Asian women and found that every 10mm Hg increase in mean arterial blood pressure was associated with a 1.9-μm (P<0.001) reduction in retinal arteriolar caliber, a 0.9° (P=0.05) reduction of retinal branching angle, and a 0.07 (P < 0.01) reduction on retinal fractal dimension, respectively.
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Abnormal morphology biases hematocrit distribution in tumor vasculature and contributes to heterogeneity in tissue oxygenation.
Miguel O. Bernabeu,Jakub Köry,James A. Grogan,Bostjan Markelc,Albert Beardo,Mayeul d'Avezac,Romain Enjalbert,Jakob Kaeppler,Nicholas Daly,James Hetherington,Timm Krüger,Philip K. Maini,Joe Pitt-Francis,Ruth J. Muschel,Tomás Alarcón,Helen M. Byrne +15 more
TL;DR: A metric to characterize tumor vasculature (mean vessel length-to-diameter ratio, λ) is introduced and demonstrated how it predicts tissue-oxygen heterogeneity and an increase in the value of λ is reported following treatment with the antiangiogenic cancer agent DC101.
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Hydraulic Anatomy and Function of Trees—Basics and Critical Developments
TL;DR: The field of tree hydraulics is experiencing a bout of activity as discussed by the authors, and significant progress has been made in understanding how water transport in trees is organized, how it integrates with other physiological processes, and what it takes for it to malfunction.
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Constructal optimization of arborescent structures with flow singularities
TL;DR: In this article, the problem of optimal channel size distribution for arborescent (ramified, branched, tree-like) networks used as flow distributors or collectors is formulated as follows: find the distribution of channel radii that minimizes total viscous dissipation (or entropy production, pumping power, pressure drop) under constraints of uniform irrigation and of total volume of channels (or of average residence time).