Journal ArticleDOI
The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
Paolo Barone,Angelo Antonini,Carlo Colosimo,Roberto Marconi,Letterio Morgante,Tania P. Avarello,Eugenio Bottacchi,Antonino Cannas,Gabriella Ceravolo,Roberto Ceravolo,Giulio Cicarelli,Roberto M. Gaglio,Rosa M. Giglia,Francesco Iemolo,M. Manfredi,Giuseppe Meco,Alessandra Nicoletti,Massimo Pederzoli,Alfredo Petrone,Antonio Pisani,Francesco E. Pontieri,Rocco Quatrale,Silvia Ramat,Rosanna Scala,Giuseppe Volpe,Salvatore Zappulla,Anna Rita Bentivoglio,Fabrizio Stocchi,Giorgio Trianni,Paolo Del Dotto +29 more
TLDR
A key role for NMS in the clinical frame of PD is supported and the need to address them specifically in clinical trials using dedicated scales is addressed.Abstract:
We performed a multicenter survey using a semistructured interview in 1,072 consecutive patients with Parkinson's disease (PD) enrolled during 12 months in 55 Italian centers to assess the prevalence of nonmotor symptoms (NMSs), their association with cognitive impairment, and the impact on patients' quality of life (QoL). We found that 98.6% of patients with PD reported the presence of NMSs. The most common were as follows: fatigue (58%), anxiety (56%), leg pain (38%), insomnia (37%), urgency and nocturia (35%), drooling of saliva and difficulties in maintaining concentration (31%). The mean number of NMS per patient was 7.8 (range, 0-32). NMS in the psychiatric domain were the most frequent (67%). Frequency of NMS increased along with the disease duration and severity. Patients with cognitive impairment reported more frequently apathy, attention/memory deficit, and psychiatric symptoms. Apathy was the symptom associated with worse PDQ-39 score but also presence of fatigue, attention/memory, and psychiatric symptoms had a negative impact on QoL. These findings further support a key role for NMS in the clinical frame of PD and the need to address them specifically in clinical trials using dedicated scales.read more
Citations
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Measuring Health: A Guide to Rating Scales and Questionnaires
Kate L Hyett,Terry Mills +1 more
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Pharmacological Treatment of Parkinson Disease: A Review
TL;DR: Strong evidence supports using levodopa and dopamine agonists for motor symptoms at all stages of Parkinson disease, and other therapies for motor and nonmotor features is less well established.
Journal ArticleDOI
The impact of non-motor symptoms on health-related quality of life of patients with Parkinson's disease.
Pablo Martinez-Martin,Carmen Rodriguez-Blazquez,Monica M. Kurtis,K. Ray Chaudhuri,K. Ray Chaudhuri +4 more
TL;DR: The Non‐Motor Symptoms Scale (NMSS) was used to assess the impact of the non‐motor symptoms on HRQoL of Parkinson's disease patients.
Journal ArticleDOI
Fatigue and fatigability in neurologic illnesses: Proposal for a unified taxonomy
TL;DR: A unified taxonomy and a novel assessment approach to addressing distinct aspects of fatigue and fatigability in clinical and research settings are proposed and it is suggested that many research questions may be better addressed by using multiple measures.
Journal ArticleDOI
Prediagnostic presentations of Parkinson's disease in primary care: a case-control study
TL;DR: These data can be incorporated into ongoing efforts to identify individuals at the earliest stages of the disease for inclusion in future trials and to help understand progression in the earliest phase of Parkinson's disease.
References
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Journal ArticleDOI
“Mini-mental state”: A practical method for grading the cognitive state of patients for the clinician
Marshal F. Folstein,Marshal F. Folstein,Susan E B Folstein,Susan E B Folstein,Paul R. McHugh,Paul R. McHugh +5 more
TL;DR: A simplified, scored form of the cognitive mental status examination, the “Mini-Mental State” (MMS) which includes eleven questions, requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
A practical method for grading the cognitive state of patients for the clinician
TL;DR: The Mini-Mental State (MMS) as mentioned in this paper is a simplified version of the standard WAIS with eleven questions and requires only 5-10 min to administer, and is therefore practical to use serially and routinely.
Journal ArticleDOI
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Margaret M. Hoehn,Melvin D. Yahr +1 more
TL;DR: Controversy over the effectiveness of therapeutic measures for parkinsonism is due partially to this wide variability and to the paucity of clinical information about the natural history of the syndrome.
Book
Measuring Health: A Guide to Rating Scales and Questionnaires
Ian McDowell,Claire Newell +1 more
TL;DR: The theory and the leading methods of measurement, all of which rely on subjective judgments in questionnaires and rating scales are described, showing readers how to select the most suitable one, apply it, and score the results.
Journal ArticleDOI
The FAB A frontal assessment battery at bedside
TL;DR: The Frontal Assessment Battery is easy to administer at bedside and is sensitive to frontal lobe dysfunction.