Journal ArticleDOI
The Relationship Between Copper, Iron, and Selenium Levels and Alzheimer Disease
Felipe Nathanael Coelho Vaz,Bárbara Luisa Fermino,Maria Vaitsa Loch Haskel,Jéssica Wouk,Guilherme Barroso Langoni de Freitas,Roberta Fabbri,Erik Montagna,João Rocha,Juliana Sartori Bonini +8 more
TLDR
Evaluating the concentrations of copper, iron, and selenium in elderly people with Alzheimer disease (AD), comparing the same parameters in a paired group of healthy people, to verify if the amount of these metals may influence the cognitive impairment progression.Abstract:
This study aimed to evaluate the concentrations of copper, iron, and selenium in elderly people with Alzheimer disease (AD), comparing the same parameters in a paired group of healthy people, in order to verify if the amount of these metals may influence the cognitive impairment progression. Patients' cognitive impairment was evaluated by Clinical Dementia Rating (CDR). The elementary quantification of erythrocytes was performed by inductively coupled plasma mass spectrometry technique. The statistical analyses were carried out by SPSS software 20.0 version, employing Shapiro-Wilk, Wilcoxon, Kruskall-Wallis, and Spearman correlation tests, considering significant results of p < 0.05. The sample was composed of 34% (n = 11) of women and 66% (n = 21) of men in each group. The AD group was characterized by a higher concentration of copper (p < 0.0001) and iron (p < 0.0001); however, there is no significant difference in selenium level. The analyses of the metal levels in different stages of AD were not significant in CDR-1, however in CDR-2 and CDR-3, elevated levels of copper and iron were observed; in CDR-3 patients, the level of selenium was lower (p < 0.008) compared to that of healthy controls. Patients with Alzheimer disease studied present increase in biometal blood levels, especially of copper and iron, and such increase can be different according to the disease stage and can cause more impairment cognitive functions in AD.read more
Citations
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Journal ArticleDOI
Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease.
TL;DR: A brief overview of the physiological roles of biometals including iron, zinc, copper, manganese, magnesium and calcium is presented, and a detailed description of their transporters and their synergistic involvement in the development of AD is provided.
Journal ArticleDOI
A selenium species in cerebrospinal fluid predicts conversion to Alzheimer's dementia in persons with mild cognitive impairment.
Marco Vinceti,Marco Vinceti,Annalisa Chiari,Marcel Eichmüller,Kenneth J. Rothman,Kenneth J. Rothman,Tommaso Filippini,Carlotta Malagoli,Jennifer Weuve,Manuela Tondelli,Giovanna Zamboni,Paolo Frigio Nichelli,Bernhard Michalke +12 more
TL;DR: Results indicate that higher amounts of a potentially toxic inorganic selenium form in cerebrospinal fluid may predict conversion from mild cognitive impairment to Alzheimer’s dementia.
Journal ArticleDOI
Molecular Mechanisms of Metal Toxicity in the Pathogenesis of Alzheimer’s Disease
Md. Tanvir Kabir,Md. Sahab Uddin,Sonia Zaman,Yesmin Begum,Ghulam Md Ashraf,May Bin-Jumah,Simona Bungau,Shaker A. Mousa,Mohamed M. Abdel-Daim,Mohamed M. Abdel-Daim +9 more
TL;DR: This article has focused on the molecular processes through which exposure to biometals and toxic metals can play roles in AD pathogenesis.
Journal ArticleDOI
Copper imbalance in Alzheimer's disease: Overview of the exchangeable copper component in plasma and the intriguing role albumin plays
TL;DR: Insight is provided into the coordination chemistry of copper in plasma with a special glance toward the exchangeable copper coordinated by albumin, to explore how aberrant regulations of this interaction are linked to the aetiology of AD.
Journal ArticleDOI
Ferrosenescence: The iron age of neurodegeneration?
TL;DR: A closer look is taken at the early markers of iron dyshomeostasis in neurodegenerative disorders, focusing on preventive strategies based on nutritional and microbiome manipulations.
References
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Journal ArticleDOI
The Clinical Dementia Rating (CDR): Current version and scoring rules
Journal ArticleDOI
Copper, iron and zinc in Alzheimer's disease senile plaques
TL;DR: Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease patients and in that of five neurologically normal control subjects using micro particle-induced X-ray emission (micro-PIXE).
Journal ArticleDOI
Release of endogenous Zn2+ from brain tissue during activity.
S. Y. Assaf,S. H. Chung +1 more
TL;DR: It is demonstrated for the first time that Zn2+ is released into the extracellular space during excitation of hippocampal slices.
Journal ArticleDOI
Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration.
TL;DR: In this article, aluminum concentrations approaching those used experimentally have been found in some regions of the brains of patients with Alzheimer's disease, which is an important pathological finding in senile and presenile dementia of the Alzheimer type.