Open AccessJournal Article
The role of cytokines in osteoarthritis pathophysiology.
TLDR
The neutralization of IL-1 and/or TNF-alpha up-regulation of MMP gene expression appears to be a logical development in the potential medical therapy of OA, and experimental evidence showing that neutralizing T NF-alpha suppressed cartilage degradation in arthritis also support such strategy.About:
This article is published in Biorheology.The article was published on 2002-01-01 and is currently open access. It has received 1005 citations till now. The article focuses on the topics: Proinflammatory cytokine & Chondrocyte.read more
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Mesenchymal stem cells: clinical applications and biological characterization
Frank Barry,J. Mary Murphy +1 more
TL;DR: This review summarizes recent findings regarding the potential clinical use of MSCs in cardiovascular, neural and orthopaedic applications.
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The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis.
TL;DR: The cytokine network in OA is put in the context of cells involved in this degenerative joint disease and the possibilities for further implementation of new therapeutic strategies are pointed.
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Osteoarthritis: toward a comprehensive understanding of pathological mechanism.
TL;DR: A full understanding of the pathological mechanism of OA development relies on the discovery of the interplaying mechanisms among different OA symptoms, including articular cartilage degradation, osteophyte formation, subchondral sclerosis and synovial hyperplasia, and the signaling pathway(s) controlling these pathological processes.
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A clinical perspective of IL-1β as the gatekeeper of inflammation
TL;DR: Evidence for the involvement of IL‐1β and the clinical results of reducing IL‐ 1β activity in this broad spectrum of inflammatory diseases are the focus of this review.
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The role of cytokines in cartilage matrix degeneration in osteoarthritis.
TL;DR: The role of proinflammatory cytokines and their roles in mediating the increased matrix degradation that characterizes the osteoarthritic cartilage lesion are focused on.