Journal ArticleDOI
The role of gaba metabolism in the convulsant and anticonvulsant actions of aminooxyacetic acid
J. D. Wood,S. J. Peesker +1 more
Reads0
Chats0
TLDR
The state of excitability of the brain following the administration of AOAA was related, within the limits of the present study, to changes in GAD activity and GABA levels, but additional data are required before the relationship can be properly evaluated.Abstract:
— At high dosage levels AOAA acted as a convulsant agent in mice and rats but in lower amounts it was an effective anticonvulsant agent against INH-induced seizures, by tripling the time to the onset of the convulsions. AOAA elevated brain GABA levels as a result of a preferential inhibition of the GABA-T enzyme system but, contrary to previous reports, the activity of the GAD enzyme system was also inhibited, even by relatively low dosage levels of AOAA. The state of excitability of the brain following the administration of AOAA was related, within the limits of the present study, to changes in GAD activity and GABA levels, but additional data are required before the relationship can be properly evaluated.read more
Citations
More filters
Journal ArticleDOI
Effect of drugs on rat brain, cerebrospinal fluid and blood GABA content.
TL;DR: The results suggest that changes in blood GABA levels after administration of inhibitors of GABA synthesis or degradation may be an indirect indicator of changes in the brain content of this amino acid.
Journal ArticleDOI
Biochemical effects in man and rat of three drugs which can increase brain GABA content.
Thomas L. Perry,Shirley Hansen +1 more
TL;DR: It is found that approximately 4 times as much AOAA is required by mouth as by parenteral injection to raise brain GABA content in the rat and that DPA given orally produced no alterations of any amino acids in rat brain.
Journal ArticleDOI
Evidence for a role of glutamate decarboxylase activity as a regulatory mechanism of cerebral excitability.
TL;DR: The results suggest that under normal conditions GABA is not being released from a storage pool specifically related to i ts synaptic function, but, instead, that the newly synthesized GABA is being liberated into the synaptic cleft (TAPIA, 1974).
Journal ArticleDOI
Aluminum-Activated Malate Transporters Can Facilitate GABA Transport.
Sunita A. Ramesh,Muhammad Kamran,Wendy Sullivan,Larissa Chirkova,Mamoru Okamoto,Fien Degryse,Mike J. McLaughlin,Matthew Gilliham,Stephen D. Tyerman +8 more
TL;DR: It is concluded that ALMTs are likely to act as both GABA and anion transporters in planta, suggestive of a role for AlMTs in communicating metabolic status.
Journal ArticleDOI
The gamma-aminobutyrate content of nerve endings (synaptosomes) in mice after the intramuscular injection of gamma-aminobutyrate-elevating agents: a possible role in anticonvulsant activity.
TL;DR: The intramuscular administration of L‐cycloserine, gabaculine, and aminooxyacetic acid caused significant, time‐dependent increases in the γ‐aminobutyric acid (GABA) content of both whole brain and synaptosomalenriched preparations obtained from the tissue, a linear relationship being observed between the two parameters.
References
More filters
Journal ArticleDOI
Subcellular distribution of the enzymes of the glutamic acid, glutamine and gamma-aminobutyric acid cycles in rat brain.
L. Salganicoff,E. M. De Robertis +1 more
TL;DR: The function of this group of amino acids seems to be related to the complex structure of the CNS and the existence of numerous compartments and metabolic pools.
Journal ArticleDOI
Some properties of L-glutamic decarboxylase in mouse brain.
Eugene Roberts,Daisy G. Simonsen +1 more
TL;DR: Experiments with hydroxylamine and α-hydrazinophenylacetic acid showed that the rate of loss of enzymic activity during preincubation of the brain homogenate with these agents was less than in absence of inhibitor, a finding consistent with the interpretation that the major mode of inhibition by carbonyltrapping agents is by combination with the holoenzyme.
Journal ArticleDOI
Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).
TL;DR: Amino-oxyacetic acid has been found to be a potent inhibitor of the enzyme γ-aminobutyric acid-α-ketoglutaric acid transaminase derived both from E. coli and mammalian brain.
Related Papers (5)
Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).
Subcellular distribution of the enzymes of the glutamic acid, glutamine and gamma-aminobutyric acid cycles in rat brain.
L. Salganicoff,E. M. De Robertis +1 more