Journal ArticleDOI
The role of gaba metabolism in the convulsant and anticonvulsant actions of aminooxyacetic acid
J. D. Wood,S. J. Peesker +1 more
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The state of excitability of the brain following the administration of AOAA was related, within the limits of the present study, to changes in GAD activity and GABA levels, but additional data are required before the relationship can be properly evaluated.Abstract:
— At high dosage levels AOAA acted as a convulsant agent in mice and rats but in lower amounts it was an effective anticonvulsant agent against INH-induced seizures, by tripling the time to the onset of the convulsions. AOAA elevated brain GABA levels as a result of a preferential inhibition of the GABA-T enzyme system but, contrary to previous reports, the activity of the GAD enzyme system was also inhibited, even by relatively low dosage levels of AOAA. The state of excitability of the brain following the administration of AOAA was related, within the limits of the present study, to changes in GAD activity and GABA levels, but additional data are required before the relationship can be properly evaluated.read more
Citations
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Journal ArticleDOI
Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment
TL;DR: A residual effect of DPA against seizures induced by pentetrazole was shown, i.e. a potentiation of the anticonvulsant properties of the second of two successive injections of Dpa, the latter being given after the decrease of the GABA levels in whole brain to control values.
Journal ArticleDOI
γ-aminobutyric acid decreases levels of messenger ribonucleic acid encoding prolactin in the rat pituitary
TL;DR: It is suggested that GABA might inhibit PRL gene expression by a direct action on lactotrophs of the adenohypophysis 3-4 days following commencement of the drug treatment.
Book ChapterDOI
Evidence for A Synthesis-Dependent Release of GABA
TL;DR: The control of neuronal activity through synaptic inhibitory mechanisms in the central nervous system (CNS) is presently well established and implies that a given neuron will fire when the inhibitory action of the controlling neuron decreases, that is, through disinhibition.
Journal ArticleDOI
Effect of combined dopaminergic and GABA-ergic stimulation on ouabain-induced epileptiform activity.
Ryszard Stach,Danuta Kacz +1 more
TL;DR: It is proposed that dopamine and GABA receptor‐stimulating agents given together might mutually potentiate their anticonvulsant activities and this hypothesis was tested on free‐moving rabbits with epileptiform activity evoked by cortical application of ouabain.
Journal ArticleDOI
Effects of inhibitors of GABA-transaminase on hole-board exploration and on temperature. Relation with effects on quasi-morphine abstinence behaviour induced by sodium dipropylacetate.
TL;DR: The results suggest that the anti-quasi-withdrawal, the sedative and the hypothermic effects are not related to each other nor related to an effect on GABA-T, but could be related to the inhibition of GAD.
References
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Journal ArticleDOI
Subcellular distribution of the enzymes of the glutamic acid, glutamine and gamma-aminobutyric acid cycles in rat brain.
L. Salganicoff,E. M. De Robertis +1 more
TL;DR: The function of this group of amino acids seems to be related to the complex structure of the CNS and the existence of numerous compartments and metabolic pools.
Journal ArticleDOI
Some properties of L-glutamic decarboxylase in mouse brain.
Eugene Roberts,Daisy G. Simonsen +1 more
TL;DR: Experiments with hydroxylamine and α-hydrazinophenylacetic acid showed that the rate of loss of enzymic activity during preincubation of the brain homogenate with these agents was less than in absence of inhibitor, a finding consistent with the interpretation that the major mode of inhibition by carbonyltrapping agents is by combination with the holoenzyme.
Journal ArticleDOI
Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).
TL;DR: Amino-oxyacetic acid has been found to be a potent inhibitor of the enzyme γ-aminobutyric acid-α-ketoglutaric acid transaminase derived both from E. coli and mammalian brain.
Related Papers (5)
Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).
Subcellular distribution of the enzymes of the glutamic acid, glutamine and gamma-aminobutyric acid cycles in rat brain.
L. Salganicoff,E. M. De Robertis +1 more