Journal ArticleDOI
The role of gaba metabolism in the convulsant and anticonvulsant actions of aminooxyacetic acid
J. D. Wood,S. J. Peesker +1 more
Reads0
Chats0
TLDR
The state of excitability of the brain following the administration of AOAA was related, within the limits of the present study, to changes in GAD activity and GABA levels, but additional data are required before the relationship can be properly evaluated.Abstract:
— At high dosage levels AOAA acted as a convulsant agent in mice and rats but in lower amounts it was an effective anticonvulsant agent against INH-induced seizures, by tripling the time to the onset of the convulsions. AOAA elevated brain GABA levels as a result of a preferential inhibition of the GABA-T enzyme system but, contrary to previous reports, the activity of the GAD enzyme system was also inhibited, even by relatively low dosage levels of AOAA. The state of excitability of the brain following the administration of AOAA was related, within the limits of the present study, to changes in GAD activity and GABA levels, but additional data are required before the relationship can be properly evaluated.read more
Citations
More filters
Journal ArticleDOI
Increased gamma-aminobutyric acid (GABA), homocarnosine and β-alanine in cerebrospinal fluid of patients treated with γ-vinyl GABA (4-amino-hex-5-enoic acid)
Jeffrey Grove,Paul J. Schechter,G. Tell,Jan Koch-Weser,Albert Sjoerdsma,J.-M. Warter,C. Marescaux,L. Rumbach +7 more
TL;DR: The results indicate that γ-vinyl GABA enters the CNS after oral administration and alters GABA metabolism by inhibition of GABA-T and suggest that such treatment may achieve therapeutic benefit in conditions where such neurochemical alterations are desirable.
Journal ArticleDOI
GABA and behavior: the role of receptor subtypes.
Raúl G. Paredes,Anders Ågmo +1 more
TL;DR: existing data are sufficient to justify the prediction that GABAergic agents, in the near future, will be much used in the field of behavioral pharmacology, and it is hoped that the present review will contribute to this.
Journal ArticleDOI
The pharmacology of GABA-transaminase inhibitors.
Journal ArticleDOI
Cellular compartments of GABA in brain and their relationship to anticonvulsant activity
Michael J. Iadarola,Karen Gale +1 more
TL;DR: The results suggest that GABAergic synapses in the midbrain may be critically involved in the control of seizure propagation and the ability of DPA, AOAA and GVG to protect against chemically- and electrically-induced seizures is directly correlated with increases in nerve terminal GABA and not related to increases in other GABA compartments
Journal ArticleDOI
Sustained drug-induced elevation of brain GABA in the rat.
Thomas L. Perry,Shirley Hansen +1 more
TL;DR: Brain GABA levels in the rat were increased by approx.
References
More filters
Journal ArticleDOI
Subcellular distribution of the enzymes of the glutamic acid, glutamine and gamma-aminobutyric acid cycles in rat brain.
L. Salganicoff,E. M. De Robertis +1 more
TL;DR: The function of this group of amino acids seems to be related to the complex structure of the CNS and the existence of numerous compartments and metabolic pools.
Journal ArticleDOI
Some properties of L-glutamic decarboxylase in mouse brain.
Eugene Roberts,Daisy G. Simonsen +1 more
TL;DR: Experiments with hydroxylamine and α-hydrazinophenylacetic acid showed that the rate of loss of enzymic activity during preincubation of the brain homogenate with these agents was less than in absence of inhibitor, a finding consistent with the interpretation that the major mode of inhibition by carbonyltrapping agents is by combination with the holoenzyme.
Journal ArticleDOI
Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).
TL;DR: Amino-oxyacetic acid has been found to be a potent inhibitor of the enzyme γ-aminobutyric acid-α-ketoglutaric acid transaminase derived both from E. coli and mammalian brain.
Related Papers (5)
Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).
Subcellular distribution of the enzymes of the glutamic acid, glutamine and gamma-aminobutyric acid cycles in rat brain.
L. Salganicoff,E. M. De Robertis +1 more