Journal ArticleDOI
The role of gaba metabolism in the convulsant and anticonvulsant actions of aminooxyacetic acid
J. D. Wood,S. J. Peesker +1 more
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TLDR
The state of excitability of the brain following the administration of AOAA was related, within the limits of the present study, to changes in GAD activity and GABA levels, but additional data are required before the relationship can be properly evaluated.Abstract:
— At high dosage levels AOAA acted as a convulsant agent in mice and rats but in lower amounts it was an effective anticonvulsant agent against INH-induced seizures, by tripling the time to the onset of the convulsions. AOAA elevated brain GABA levels as a result of a preferential inhibition of the GABA-T enzyme system but, contrary to previous reports, the activity of the GAD enzyme system was also inhibited, even by relatively low dosage levels of AOAA. The state of excitability of the brain following the administration of AOAA was related, within the limits of the present study, to changes in GAD activity and GABA levels, but additional data are required before the relationship can be properly evaluated.read more
Citations
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Envolvimento do sistema GABAérgico nas alterações comportamentais eletrencefalográficas e neuroquímicas induzidas pela injeção de metilmalonato no ventrículo de ratos
TL;DR: In this paper, the authors investigated the involvement of GABAergic mechanisms in the convulsions induced by methylmalonic acid (MMA) and found that they are involved in the seizure.
Journal ArticleDOI
Brain energy metabolism in mice exposed to oxygen at 1 atmosphere absolute.
TL;DR: The continual decrease in AMP is of considerable importance because of its direct response to ATP via adenylate kinase reaction, and the ATP and ADP values exhibit a later increase to a constant level during the full time of exposure up to 50 h.
Journal ArticleDOI
Gamma-aminobutyric acid controls the mouse hypothalamic-pituitary-testicular response to the presence of female.
Naumenko Ev,L.I. Serova +1 more
TL;DR: It is concluded that the inhibitory effect of emotional stress on female-induced activation of testicular endocrine function is mediated, at least in part, via activation of bicuculline-sensitive receptors.
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Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine
TL;DR: In this article , the effects of C. giganteus decoction in rat model induced by pilocarpine were evaluated in the Elevated Plus Maze and Open Field Test and the number of rearing, crossing, grooming, defecation and center time were registered.
Journal ArticleDOI
Anticonvulsant effects of Cymbopogon giganteus extracts with possible effects on fully kindled seizures and anxiety in experimental rodent model of mesio-temporal epilepsy induced by pilocarpine.
TL;DR: In this paper, the authors evaluated the antiepileptic, status post-epilepticus and anxiolytic effects of Cymbopogon giganteus decoction in rat model induced by pilocarpine.
References
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Journal ArticleDOI
Subcellular distribution of the enzymes of the glutamic acid, glutamine and gamma-aminobutyric acid cycles in rat brain.
L. Salganicoff,E. M. De Robertis +1 more
TL;DR: The function of this group of amino acids seems to be related to the complex structure of the CNS and the existence of numerous compartments and metabolic pools.
Journal ArticleDOI
Some properties of L-glutamic decarboxylase in mouse brain.
Eugene Roberts,Daisy G. Simonsen +1 more
TL;DR: Experiments with hydroxylamine and α-hydrazinophenylacetic acid showed that the rate of loss of enzymic activity during preincubation of the brain homogenate with these agents was less than in absence of inhibitor, a finding consistent with the interpretation that the major mode of inhibition by carbonyltrapping agents is by combination with the holoenzyme.
Journal ArticleDOI
Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).
TL;DR: Amino-oxyacetic acid has been found to be a potent inhibitor of the enzyme γ-aminobutyric acid-α-ketoglutaric acid transaminase derived both from E. coli and mammalian brain.
Related Papers (5)
Studies on the GABA pathway. I. The inhibition of gamma-aminobutyric acid-alpha-ketoglutaric acid transaminase in vitro and in vivo by U-7524 (amino-oxyacetic acid).
Subcellular distribution of the enzymes of the glutamic acid, glutamine and gamma-aminobutyric acid cycles in rat brain.
L. Salganicoff,E. M. De Robertis +1 more