Journal ArticleDOI
The role of human papillomavirus in the increased incidence of base of tongue cancer
Per Attner,Juan Du,Anders Näsman,Lalle Hammarstedt,Torbjörn Ramqvist,Johan Lindholm,Linda Marklund,Tina Dalianis,Tina Dalianis,Eva Munck-Wikland +9 more
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TLDR
The incidence of base of tongue cancer, as well as the proportion of HPV‐positive tumors, has increased in Sweden during the study period, suggesting that HPV may contribute to this increase.Abstract:
Numerous reports have shown that the incidence for oropharyngeal cancer is increasing and that human papillomavirus (HPV) is a risk factor. However, few studies have investigated the specific subsites of the oropharynx. Following our previous research on tonsillar cancer, we assessed the increase in the incidence of base of tongue cancer and the prevalence of HPV in this disease. Between 1998 and 2007, 109 patients were diagnosed for base of tongue cancer in Stockholm county. Ninety-five paraffin-embedded diagnostic tumor biopsies from patients were obtained and tested for HPV, both by general HPV PCR and HPV-16/HPV-33 type-specific PCR. Expression of HPV-16 RNA was analyzed to confirm E6 and/or E7 expression. Incidence data were obtained from the Swedish Cancer Registry. An overall increase in the incidence of base of tongue cancer from 0.15/100,000 person-years during 1970-1974 to 0.47/100,000 person-years during 2005-2007 was found in Sweden. The prevalence of HPV in base of tongue cancer in Stockholm county increased from 58% during 1998-2001 to 84% during 2004-2007 (p < 0.05). In the HPV-positive tumors, HPV-16 dominated (86%) but interestingly, HPV33 was detected in as many as 10%. E6 and/or E7 RNA were found in 85% of the samples tested. The incidence of base of tongue cancer, as well as the proportion of HPV-positive tumors, has increased in Sweden during the study period, suggesting that HPV may contribute to this increase.read more
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Journal ArticleDOI
HPV-assoziierte oropharyngeale Karzinome
TL;DR: Carcinomas of the oropharynx with association to high-risk types of human papillomavirus have been identified as a new tumour entity with favourable prognosis, distinct from classical nicotine- and alcohol-associated carcinoma.
Journal ArticleDOI
Human Papilloma Virus-Induced Head and Neck Cancer
TL;DR: These HPV-induced head and neck cancers differ in their biology and prognosis from those neoplasms induced by tobacco or ethanol, and are affecting a different demographic group consisting mainly of younger, nonsmoking, males.
Journal ArticleDOI
Post-Treatment Neck Dissection of Tonsillar and Base of Tongue Squamous Cell Carcinoma in the Era of PET-CT, HPV, and p16
David Landin,Anders Näsman,Sara Jonmarker Jara,Lalle Hammarstedt-Nordenvall,Eva Munck-Wikland,Tina Dalianis,Linda Marklund +6 more
TL;DR: FDG PET-CT 12 weeks after RT/CRT is useful, but not completely reliable for finding all the metastases of HPV-associated TSCC/BOTSCC, Nonetheless, the data indicate that an ND could be more selectively guided by FDGPET-CT.
Journal ArticleDOI
A pilot study on the identification of human papillomavirus genotypes in tongue cancer samples from a single institution in Ecuador.
G M Delgado Ramos,Thomas G. Cotter,L Flor Ramos,V Torres Floril,G A Ramos Martinez,J C Ruiz-Cabezas +5 more
TL;DR: HPV was identified in almost half of the tongue cancer samples, with subtypes 33 and 67 being the most common, which suggested that HPV played an important role in this disease in the population studied.
Book ChapterDOI
Patterns and Trends in HPV-Related Oral Cancer and Other HPV-Associated Cancers
TL;DR: This work aims to learn from the US status with other HPV associated cancers, to help inform us about the relative status of HPV-oral cancer, in the window of the introduction of the HPV vaccine.
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Journal ArticleDOI
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TL;DR: Oropharyngeal cancer was significantly associated with oral HPV type 16 (HPV-16) infection, and the degree of association increased with the number of vaginal-sex and oral-sex partners, among subjects with or without the established risk factors of tobacco and alcohol use.
Journal ArticleDOI
Incidence Trends for Human Papillomavirus–Related and –Unrelated Oral Squamous Cell Carcinomas in the United States
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