Journal ArticleDOI
The role of human papillomavirus in the increased incidence of base of tongue cancer
Per Attner,Juan Du,Anders Näsman,Lalle Hammarstedt,Torbjörn Ramqvist,Johan Lindholm,Linda Marklund,Tina Dalianis,Tina Dalianis,Eva Munck-Wikland +9 more
Reads0
Chats0
TLDR
The incidence of base of tongue cancer, as well as the proportion of HPV‐positive tumors, has increased in Sweden during the study period, suggesting that HPV may contribute to this increase.Abstract:
Numerous reports have shown that the incidence for oropharyngeal cancer is increasing and that human papillomavirus (HPV) is a risk factor. However, few studies have investigated the specific subsites of the oropharynx. Following our previous research on tonsillar cancer, we assessed the increase in the incidence of base of tongue cancer and the prevalence of HPV in this disease. Between 1998 and 2007, 109 patients were diagnosed for base of tongue cancer in Stockholm county. Ninety-five paraffin-embedded diagnostic tumor biopsies from patients were obtained and tested for HPV, both by general HPV PCR and HPV-16/HPV-33 type-specific PCR. Expression of HPV-16 RNA was analyzed to confirm E6 and/or E7 expression. Incidence data were obtained from the Swedish Cancer Registry. An overall increase in the incidence of base of tongue cancer from 0.15/100,000 person-years during 1970-1974 to 0.47/100,000 person-years during 2005-2007 was found in Sweden. The prevalence of HPV in base of tongue cancer in Stockholm county increased from 58% during 1998-2001 to 84% during 2004-2007 (p < 0.05). In the HPV-positive tumors, HPV-16 dominated (86%) but interestingly, HPV33 was detected in as many as 10%. E6 and/or E7 RNA were found in 85% of the samples tested. The incidence of base of tongue cancer, as well as the proportion of HPV-positive tumors, has increased in Sweden during the study period, suggesting that HPV may contribute to this increase.read more
Citations
More filters
Journal ArticleDOI
Human papillomavirus and oropharyngeal cancer, the epidemics, and significance of additional clinical biomarkers for prediction of response to therapy (Review)
TL;DR: Patients with HPV-positive OPSCC, where the majority are men, particularly never-smokers have a better clinical outcome, and could with somewhat tapered treatment maintain excellent survival, avoiding some of the severe side effects along with intensified treatment.
Journal ArticleDOI
Prevalence of human papillomavirus and survival in oropharyngeal cancer other than tonsil or base of tongue cancer
Linda Marklund,Anders Näsman,Torbjörn Ramqvist,Tina Dalianis,Eva Munck-Wikland,Lalle Hammarstedt +5 more
TL;DR: The prevalence of HPV and/or p16 is much lower in OOSCC compared to earlier reports including all OSCC, or tonsillar‐ and base of tongue cancer alone and HPV and p16 had no impact on clinical outcome in OSCC in this study.
Journal ArticleDOI
Impact of HPV in Oropharyngeal Cancer.
Linda Marklund,Lalle Hammarstedt +1 more
TL;DR: The HPV-positive tumours are today recognized as a distinct subset of head and neck cancers with its own clinopathological and risk profile and have a significantly improved prognosis regardless of treatment strategy.
Journal ArticleDOI
HPV status in patients with head and neck of carcinoma of unknown primary site: HPV, tobacco smoking, and outcome
Silke Tribius,Anna S. Hoffmann,Sophie Bastrop,Tibor Görögh,Jochen Haag,Christoph Röcken,Till S. Clauditz,Tobias Grob,Waldemar Wilczak,Pierre Tennstedt,Aileen Borcherding,Cordula Petersen,Markus Hoffmann +12 more
TL;DR: This study, the largest to date investigating HPV status in head and neck CUP, identified HPV and p16 overexpression in over one-third of patients, and tobacco smoking history appeared to affect survival in HPV+/p16+ patients.
Journal ArticleDOI
Interventions for the treatment of oral cavity and oropharyngeal cancer: radiotherapy.
Anne-Marie Glenny,Susan Furness,Helen V Worthington,David I. Conway,Richard Oliver,Jan E Clarkson,Michaelina Macluskey,Sue Pavitt,Kelvin K. W. Chan,Paul Brocklehurst +9 more
TL;DR: To determine which radiotherapy regimens for oral cavity and oropharyngeal cancers result in increased overall survival, disease free survival, progression free survival and locoregional control, randomised controlled trials were conducted.
References
More filters
Journal ArticleDOI
Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
Journal ArticleDOI
Global cancer statistics, 2002.
TL;DR: There are striking variations in the risk of different cancers by geographic area, most of the international variation is due to exposure to known or suspected risk factors related to lifestyle or environment, and provides a clear challenge to prevention.
Journal ArticleDOI
Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers
Maura L. Gillison,Wayne M. Koch,Randolph B. Capone,Michael Spafford,William H. Westra,Li Wu,Marianna Zahurak,Richard W. Daniel,Michael P. Viglione,David Eric Symer,Keerti V. Shah,David Sidransky +11 more
TL;DR: It is suggested that HPV-positive oropharyngeal cancers comprise a distinct molecular, clinical, and pathologic disease entity that is likely causally associated with HPV infection and that has a markedly improved prognosis.
Journal ArticleDOI
Case-control study of human papillomavirus and oropharyngeal cancer.
Aimée R. Kreimer,Raphael P. Viscidi,Michael Pawlita,Carole Fakhry,Wayne M. Koch,William H. Westra,Maura L. Gillison +6 more
TL;DR: Oropharyngeal cancer was significantly associated with oral HPV type 16 (HPV-16) infection, and the degree of association increased with the number of vaginal-sex and oral-sex partners, among subjects with or without the established risk factors of tobacco and alcohol use.
Journal ArticleDOI
Incidence Trends for Human Papillomavirus–Related and –Unrelated Oral Squamous Cell Carcinomas in the United States
TL;DR: The proportion of OSCCs that are potentially HPV-related increased in the United States from 1973 to 2004, perhaps as a result of changing sexual behaviors.