Journal ArticleDOI
Phospholipid methylation and biological signal transmission
Fusao Hirata,Julius Axelrod +1 more
TLDR
The methylation of phospholipids is coupled to Ca2+ influx and the release of arachidonic acid, lysophosphatidylcholine, and prostaglandins, resulting in the generation of adenosine 3',5'-monophophate in many cell types, release of histamine in mast cells and basophils, mitogenesis in lymphocytes, and chemotaxis in neutrophils.Abstract:
Many types of cells methylate phospholipids using two methyltransferase enzymes that are asymmetrically distributed in membranes. As the phospholipids are successively methylated, they are translocated from the inside to the outside of the membrane. When catecholamine neurotransmitters, lectins, immunoglobulins or chemotaxic peptides bind to the cell surface, they stimulate the methyltransferase enzymes and reduce membrane viscosity. The methylation of phospholipids is coupled to Ca2+ influx and the release of arachidonic acid, lysophosphatidylcholine, and prostaglandins. These closely associated biochemical changes facilitate the transmission of many signals through membranes, resulting in the generation of adenosine 3',5'-monophophate in many cell types, release of histamine in mast cells and basophils, mitogenesis in lymphocytes, and chemotaxis in neutrophils.read more
Citations
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Cell Damage in the Brain: A Speculative Synthesis
TL;DR: In this article, it was shown that the clinically most important conditions leading to brain cell death are those associated with cerebrovascul ar dise ase, particularly stroke, and with head trauma.
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The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function
Journal ArticleDOI
How is the level of free arachidonic acid controlled in mammalian cells
TL;DR: In order to move forward both conceptually and experimentally it is necessary to take a critical look at the complexities and problems associated with studying arachidonate liberation.
Journal ArticleDOI
Chemistry and metabolism of lipids in the vertebrate retina
Journal ArticleDOI
Lipid intermolecular hydrogen bonding: influence on structural organization and membrane function.
TL;DR: The tendency of certain lipids to self-associate, their asymmetric distribution in SUVs, their preferential association with cholesterol in non-cocrystallizing mixtures, their temperature-induced transitions to the hexagonal phase and their inhibitory effect on penetration of hydrophobic residues of proteins partway into the bilayer can all be explained by their participation in intermolecular hydrogen bonding interactions.
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