The Saccharomyces cerevisiae Cell Cycle
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The bibliography is intended more as a guide to the literature than as a historically accurate record of the development of the field; the authors apologize to the earlier workers whose contributions thus get less explicit credit than they deserve.Abstract:
INTRODUCTION The cell cycle is the process of vegetative (asexual) cellular reproduction; in a normal cell cycle, one cell gives rise to two cells that are genetically identical to the original cell. Questions about the cell cycle can be conveniently divided into two categories. First, one can ask how a cell carries out a cell cycle, once it has undertaken to do so. Into this category fall questions about the morphological and biochemical aspects of cell-cycle events and about the mechanisms that ensure their temporal and functional coordination. Second, one can ask what determines when a cell will undertake a cell cycle, or how the overall control of cell proliferation is achieved. Into this category fall questions about the coordination of successive cell cycles, the coordination of growth with division, the coordination of cell proliferation with the availability of essential nutrients, and the selection of developmental alternatives. In the text that follows, we consider these two categories of questions in turn. Our bibliography is intended more as a guide to the literature than as a historically accurate record of the development of the field; we apologize to the earlier workers whose contributions thus get less explicit credit than they deserve. HOW DOES A CELL CARRY OUT A CELL CYCLE? As has often been noted, successful completion of a cell cycle requires a cell to integrate the processes that duplicate the cellular material with the processes that partition the duplicated material into two viable daughter cells. Another useful formulation of the...read more
Citations
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Journal ArticleDOI
SCF and Cullin/RING H2-Based Ubiquitin Ligases
TL;DR: This review is focused on a conserved ubiquitin ligase complex known as SCF that plays a key role in marking a variety of regulatory proteins for destruction by the 26S proteasome.
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Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: Regulation by starvation and RAS
TL;DR: Pseudohyphal growth requires the polar budding pattern of a/alpha diploid cells; haploid axially budding cells of identical genotype cannot undergo this dimorphic transition.
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S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function.
M.A. Hoyt,L. Totis,B.T. Roberts +2 more
TL;DR: In this article, the authors identified mutant strains of S. cerevisiae that fail to properly arrest their cell cycles at mitosis in response to the loss of microtubule function.
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Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.
Dawn E. Quelle,Richard A. Ashmun,Sheila A. Shurtleff,Jun-ya Kato,Dafna Bar-Sagi,Martine F. Roussel,Charles J. Sherr +6 more
TL;DR: Mammalian D-type cyclins are growth factor-regulated, delayed early response genes that are presumed to control progression through the G1 phase of the cell cycle by governing the activity of cyclin-dependent kinases, and cyclin D1, and most likely D2, are rate limiting for G1 progression.
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In yeast, RAS proteins are controlling elements of adenylate cyclase
T. Toda,Isao Uno,Tatsuo Ishikawa,Scott Powers,Tohru Kataoka,Daniel Broek,Scott J. Cameron,James R. Broach,Kunihiro Matsumoto,Michael Wigler +9 more
TL;DR: S. cerevisiae strains containing RAS2val19, a Ras2 gene with a missense mutation analogous to one that activates the transforming potential of mammalian ras genes, have growth and biochemical properties strikingly similar to yeast strains carrying IAC or bcy1.
References
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Genetic Control of the Cell Division Cycle in Yeast
TL;DR: Two features which distinguish the cell cycle of Saccharomyces cerevisiae from most other eukaryotes are particularly useful for an analysis of the gene functions that control the cell division cycle.
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GENETIC CONTROL OF THE CELL DIVISION CYCLE IN YEAST: V. GENETIC ANALYSIS OF cdc MUTANTS
TL;DR: The gene products that are defined by the cdc cistrons are essential for the completion of the cell cycle in haploids of a and alpha mating type and in a/alpha diploid cells and the same genes control thecell cycle in each of these stages of the life cycle.
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Macromolecule Synthesis in Temperature-sensitive Mutants of Yeast
TL;DR: The mutants were tested for loss of viability, change in morphology, increase in cell number, and ability to synthesize protein, ribonucleic acid (RNA), and deoxyribonuclear acid (DNA) after a shift from 23 to 36 C as mentioned in this paper.
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Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis
TL;DR: It is concluded that bud emergence is not a necessary prerequisite for the completion of DNA replication but is apparently necessary for nuclear division and Cytokinesis and cell separation are not necessary prerequisites for bud emergence, DNA replication, or nuclear division.