The significant effect of endometriosis on physical, mental and social wellbeing: results from an international cross-sectional survey
A.A. de Graaff,Thomas D'Hooghe,Gerard A.J. Dunselman,Carmen D. Dirksen,Lone Hummelshoj,Steven Simoens,Attila Bokor,Iris Brandes,Valentin Brodszky,Michel Canis,Giorgio L Colombo,Thomas DeLeire,Tommaso Falcone,B Graham,Gülden Halis,Andrew W Horne,Omar Kanj,Jens Jørgen Kjer,Jens Halkjær Kristensen,Dan I. Lebovic,Matthias J. Müller,Paola Viganò,Marcel Wullschleger +22 more
TLDR
Quality of life was decreased in all eight dimensions of the SF-36v2 compared with norm-based scores from a general US population and Multivariate regression analysis showed that number of co-morbidities, chronic pain and dyspareunia had an independent negative effect on both the physical and mental component of the Short Form 36 version 2.Abstract:
participants/materials,setting,methods: Women diagnosed with endometriosis who had at least one contact related to endometriosis-associated symptoms during 2008 with a participating centre were enrolled into the study. The study investigated the effect of endometriosis on education, work and social wellbeing, endometriosis-associated symptoms and health-related quality of life, by using questions obtained from the World Endometriosis Research Foundation (WERF) GSWH instrument (designed and validated for the WERF Global Study on Women’s Health) and the Short Form 36 version 2 (SF-36v2). main results and the role of chance: Of 3216 women invited to participate in the study, 1450 (45%) provided informed consent and out of these, 931 (931/3216 ¼ 29%) returned the questionnaires. Endometriosis had affected work in 51% of the women and affected relationships in 50% of the women at some time during their life. Dysmenorrhoea was reported by 59%, dyspareunia by 56% and chronic pelvic pain by 60% of women. Quality of life was decreased in all eight dimensions of the SF-36v2 compared with norm-based scores from a general US population (all P , 0.01). Multivariate regression analysis showed that number of co-morbidities, chronic pain and dyspareunia had an independent negative effect on both the physical and mental component of the SF-36v2. limitations,reasonsforcaution: The fact that women were enrolled in tertiary care centres could lead to a possible over-representation of women with moderate-to-severe endometriosis, because the participating centres typically treat more complex and referred cases of endometriosis. The response rate was relatively low. Since there was no Institute Review Board approval to do a non-responder investigation on basic characteristics, some uncertainty remains regarding the representativeness of the investigated population. wider implications of the findings: This international multicentre survey represents a large group of women with endometriosis, in all phases of the disease, which increases the generalizability of the data. Women still suffer from frequent symptoms, despite tertiary care management, in particular chronic pain and dyspareunia. As a result their quality of life is significantly decreased. A patient-centred approach withread more
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Journal ArticleDOI
Endometriosis: pathogenesis and treatment
TL;DR: Endometriosis is estrogen-dependent, manifests during reproductive years and is associated with pain and infertility, while lesion eradication is considered a fertility-enhancing procedure, the benefit on reproductive performance is moderate.
Journal ArticleDOI
Cancer-Associated Mutations in Endometriosis without Cancer
Michael S. Anglesio,Nickolas Papadopoulos,Ayse Ayhan,Tayyebeh M. Nazeran,Michaël Noë,Hugo M. Horlings,Amy Lum,Siân Jones,Janine Senz,Tamer Seckin,Julie Ho,Ren-Chin Wu,Vivian Lac,Hiroshi Ogawa,Basile Tessier-Cloutier,Rami Alhassan,Amy Wang,Yuxuan Wang,Joshua D. Cohen,Fontayne Wong,Adnan Hasanovic,Natasha L. Orr,Ming Zhang,Maria Popoli,Wyatt Mcmahon,Laura D. Wood,Austin Mattox,Catherine Allaire,James H. Segars,Christina Williams,Cristian Tomasetti,Niki Boyd,Kenneth W. Kinzler,C. Blake Gilks,Luis A. Diaz,Tian Li Wang,Bert Vogelstein,Paul J. Yong,David G. Huntsman,Ie Ming Shih +39 more
TL;DR: It is found that lesions in deep infiltrating endometriosis, which are associated with virtually no risk of malignant transformation, harbor somatic cancer driver mutations.
Journal ArticleDOI
Impact of endometriosis on women’s lives: a qualitative study
TL;DR: The findings show that endometriosis impacts negatively on different aspects of women’s lives, and a better understanding of these findings could help to decrease the negative impact of endometRIosis by guiding service delivery and future research to meet more effectively the needs of women and teenagers with this condition.
Journal ArticleDOI
Impact of endometriosis on quality of life and mental health: pelvic pain makes the difference
Federica Facchin,Giussy Barbara,Emanuela Saita,Paola Mosconi,Anna Roberto,Luigi Fedele,Paolo Vercellini +6 more
TL;DR: Endometriosis patients with pelvic pain had poorer quality of life and mental health as compared with those with asymptomatic endometRIosis and the healthy controls, and healthy, pain-free controls.
References
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Book
Statistical Power Analysis for the Behavioral Sciences
TL;DR: The concepts of power analysis are discussed in this paper, where Chi-square Tests for Goodness of Fit and Contingency Tables, t-Test for Means, and Sign Test are used.
Book
SF-36 health survey: Manual and interpretation guide
TL;DR: TheSF-36 is a generic health status measure which has gained popularity as a measure of outcome in a wide variety of patient groups and social and the contribution of baseline health, sociodemographic and work-related factors to the SF-36 Health Survey: manual and interpretation guide is tested.
Journal Article
Revised American Fertility Society classification of endometriosis: 1985
W. C. Andrews,V. C. Buttram,S. J. Behrman,E. Carmichael,M. R. Cohen,P. Dmowski,R. D. Eward,David S. Guzick,H. W. Jones,R. W. Kistner,J. C. Weed,Charles B. Hammond,H. H. Thomas +12 more
Journal ArticleDOI
ESHRE guideline for the diagnosis and treatment of endometriosis
Stephen Kennedy,Agneta Bergqvist,Charles Chapron,Thomas D'Hooghe,Gerard A.J. Dunselman,Robert R. Greb,Lone Hummelshoj,Andrew M. Prentice,Ertan Saridogan +8 more
TL;DR: A working group was convened comprised of practising gynaecologists and experts in evidence-based medicine from Europe, as well as an endometriosis self-help group representative, and the guideline was developed and refined.
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