Journal ArticleDOI
Thermal stability, mechanical properties and reducible cross-links of rat tail tendon in experimental diabetes.
TLDR
The results indicate that stabilization of collagen fibres in diabetes does not follow the same pattern as that seen in normal ageing.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1981-10-12. It has received 157 citations till now.read more
Citations
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Journal ArticleDOI
Nonenzymatic glycosylation and the pathogenesis of diabetic complications.
TL;DR: Excessive formation of both types of nonenzymatic glycosylation product appears to be the common biochemical link between chronic hyperglycemia and a number of pathophysiologic processes potentially involved in the development of long-term diabetic complications.
Journal ArticleDOI
Mechanisms of maturation and ageing of collagen
TL;DR: An understanding of these mechanisms is now leading to the development of inhibitors of glycation and compounds capable of cleaving the cross-links, thus alleviating the devastating effects of ageing.
Journal ArticleDOI
Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes
R.G. Paul,Allen J. Bailey +1 more
TL;DR: The nature of these glycation cross-links is now being unravelled and this knowledge is crucial in any attempt to inhibit these deleterious glycation reactions.
Journal ArticleDOI
Influence of cross-link structure, density and mechanical properties in the mesoscale deformation mechanisms of collagen fibrils
TL;DR: It is suggested that both cross-link density and type dictate the stiffness of large deformation regime by increasing the number of interconnected molecules while cross-links mechanical properties determine the failure strain and strength of the fibril.
Journal ArticleDOI
The increase in denaturation temperature following cross-linking of collagen is caused by dehydration of the fibres.
TL;DR: The "polymer-in-a-box" mechanism of stabilization, previously proposed to explain the effect of dehydration on the thermal properties of native tendon, explained the new data also.
References
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Journal ArticleDOI
The chemistry of the collagen cross-links. Age-related changes in the reducible components of intact bovine collagen fibres.
TL;DR: The change in the amounts of the three major reducible cross-links was followed throughout the bovine-life span and some new reducible components increased during maturation, but their characterization as N(epsilon)-glycosylamines demonstrated that they were not related to the lysine-derived aldehyde components.
Journal Article
The roles of hyaluronic acid, collagen and elastin in the mechanical properties of connective tissues.
H Oxlund,T T Andreassen +1 more
TL;DR: The study shows that collagen is the component which is mainly responsible for the tensile strength of skin and aorta, while the toe-part of the 'stress'-strain curve of aortA is determined by both elastin and collagen.
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Studies on the human glomerular basement membrane. Composition, nature of the carbohydrate units and chemical changes in diabetes mellitus.
TL;DR: An overproduction in the diabetic state of those subunits of the basement membrane that are rich in hydroxylysmej and its glycosidically linked disaccharide unit may lead to an abnormal packing of the peptide chains and thereby form the basis for the detective filtration function observed in diabetes.
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Isometric tension developed during heating of collagenous tissues. Relationships with collagen cross-linking.
TL;DR: Determination of the isometric tension developed in heated tissues provides a rapid assay useful for obtaining preliminary information on the cross-linking of collagen fibres in normal and pathological situations.