Journal ArticleDOI
Thrombosis in myeloproliferative neoplasms: update in pathophysiology.
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In this article, a review summarizes high-impact research in myeloproliferative neoplasms (MPN) from the last 18 months, with a particular focus on basic science findings.Abstract:
Purpose of review This review summarizes high-impact research in myeloproliferative neoplasms (MPN) from the last 18 months, with a particular focus on basic science findings. Recent findings A pseudo-hypoxia state with stabilization of hypoxia-inducible factor (HIFα exists that is central to cell growth, cell renewal, inflammation, and thrombotic potential in MPN hematopoietic cells. Summary HIFα and inflammatory pathways are new therapeutic targets in MPN, with the potential to ameliorate thrombotic risk and perhaps eradicate mutant progenitor cells.read more
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Journal ArticleDOI
Thrombosis in myeloproliferative neoplasms: A clinical and pathophysiological perspective
Sarah Kelliher,Anna Falanga +1 more
TL;DR: In this article, the authors outline the incidence, nature, and risk factors for thrombosis in MPNs, give an overview of the mechanisms underlying hypercoagulability and discusses prevention and treatment considerations.
Journal ArticleDOI
Clinical features associated with thrombotic events in children with myeloproliferative neoplasms
TL;DR: Myeloproliferative neoplasms are rare clonal bone marrow disorders characterized by overproduction of mature blood cells, thrombotic complications, and predisposition to progress to acute myeloid leukemia.
Journal ArticleDOI
Thrombosis in Acute Myeloid Leukemia: Pathogenesis, Risk Factors and Therapeutic Challenges
M. Olivi,Giuseppe Lanzarone,Giulia Arrigo,Federica Martella,Vincenzo Apolito,Carolina Secreto,Roberto Freilone,Benedetto Bruno,Ernesta Audisio,Dario Ferrero,Eloise Beggiato,Marco Cerrano +11 more
References
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Journal ArticleDOI
The evolutionary dynamics and fitness landscape of clonal hematopoiesis
Caroline Watson,A. L. Papula,Gladys Y. P. Poon,Wing Hing Wong,Andrew L. Young,Todd E. Druley,Daniel S. Fisher,Jamie R. Blundell +7 more
TL;DR: It is shown that positive selection, not drift, is the major force shaping clonal hematopoiesis, and bounds on the number of hematoietic stem cells are provided, and the fitness advantages of key pathogenic variants, at single-nucleotide resolution, as well as the distribution of fitness effects within commonly mutated driver genes.
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Monocyte Conversion During Inflammation and Injury
TL;DR: A brief review of monocytes in mice highlights the plasticity of monocyte subsets and their conversion during inflammation and injury.
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The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis
Trevor P. Fidler,Chenyi Xue,M. Yalcinkaya,Brian Hardaway,Sandra Abramowicz,Tong Xiao,Wenli Liu,David G. Thomas,Mohammad Ali Hajebrahimi,Joachim Pircher,Carlos Silvestre-Roig,Andriana G. Kotini,Larry Luchsinger,Ying Wei,Marit Westerterp,Marit Westerterp,Hans-Willem Snoeck,Eirini P. Papapetrou,Christian Schulz,Steffen Massberg,Oliver Soehnlein,Oliver Soehnlein,Benjamin L. Ebert,Benjamin L. Ebert,Ross L. Levine,Muredach P. Reilly,Peter Libby,Nan Wang,Alan R. Tall +28 more
TL;DR: This paper showed that increased proliferation and glycolytic metabolism in Jak2VF macrophages lead to DNA replication stress and activation of the AIM2 inflammasome, thereby aggravating atherosclerosis.
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Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia.
Neha Gupta,Anita Sahu,Amit Prabhakar,Tathagata Chatterjee,Tarun Tyagi,Babita Kumari,N. A. Khan,Nair,Nitin Bajaj,Manish Sharma,Mohammad Z. Ashraf +10 more
TL;DR: It is proposed that an early proinflammatory state in the venous milieu, orchestrated by the HIF-induced NLRP3 inflammasome complex, is a key determinant of acute thrombotic events during hypoxic conditions.
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Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2 V617F Mice.
Wei Wang,Wenli Liu,Wenli Liu,Trevor P. Fidler,Ying Wang,Yang Tang,Brittany Woods,Carrie L. Welch,Bishuang Cai,Carlos Silvestre-Roig,Ding Ai,Yong-Guang Yang,Andrés Hidalgo,Andrés Hidalgo,Oliver Soehnlein,Oliver Soehnlein,Ira Tabas,Ross L. Levine,Alan R. Tall,Nan Wang +19 more
TL;DR: Hematopoietic Jak2VF expression promotes early lesion formation and increased complexity in advanced atherosclerosis, likely contributing to plaque instability.