Thromboxane and prostacyclin changes during cardiopulmonary bypass with and without pulsatile flow.
W.David Watkins,Myron B. Peterson,Daniel L. Kong,Katsuakira Kono,Mortimer J. Buckley,Frederick H. Levine,Daniel M. Philbin +6 more
TLDR
Pulsatile flow significantly alters prostacyclin and thromboxane profiles during cardiopulmonary bypass and favors production of the coronary vasodilator and platelet disaggregant prostacy Clin.About:
This article is published in The Journal of Thoracic and Cardiovascular Surgery.The article was published on 1982-08-01 and is currently open access. It has received 110 citations till now. The article focuses on the topics: Thromboxane & Thromboxane B2.read more
Citations
More filters
Journal ArticleDOI
Complications of the COX-2 Inhibitors Parecoxib and Valdecoxib after Cardiac Surgery
Nancy A. Nussmeier,Andrew Whelton,Mark T. Brown,Richard M. Langford,Andreas Hoeft,Joel L. Parlow,Steven W. Boyce,Kenneth M. Verburg +7 more
TL;DR: The use of parecoxib and valdecoxib after CABG was associated with an increased incidence of cardiovascular events, arousing serious concern about the use of these drugs in such circumstances.
Journal ArticleDOI
High-dose aprotinin therapy: a review of the first five years' experience.
TL;DR: The aims of this review are to discuss briefly the chemistry of aprotinin and the background to the use of the dose regimen currently recommended, and to summarize some of the data showing the efficacy of the drug given in a variety of cardiac, vascular, and transplantation procedures.
Journal ArticleDOI
A randomized study of the influence of perfusion technique and pH management strategy in 316 patients undergoing coronary artery bypass surgery:: I. mortality and cardiovascular morbidity
TL;DR: In this article, a double-blind, randomized study comparing outcomes after alpha-stat or pH-stat management and pulsatile or nonpulsatile perfusion during moderate hypothermic cardiopulmonary bypass was undertaken in 316 patients undergoing coronary artery bypass operations.
Journal ArticleDOI
Splanchnic ischaemia and its role in multiple organ failure.
L. Landow,L. W. Andersen +1 more
TL;DR: The data indicate that inadequate gut perfusion leads to a measurable imbalance between oxygen delivery and the needs of the tissues, i.e., ischaemia, which leads to multiple organ failure.
Journal ArticleDOI
Blood platelets in cardiopulmonary bypass operations. Recovery occurs after initial stimulation, rather than continual activation.
TL;DR: Transmission electron microscopic analysis of the arterial filter and scanning electron microscopic findings of circulating platelets indicated that the release products in plasma were due not only to platelet lysis but also to a limited extent to secondary aggregation.
References
More filters
Journal ArticleDOI
Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac ateries and inhibits platelet aggregation.
TL;DR: A biochemical interaction between platelets and vessel wall is postulated by which platelets feed the vessel wall with prostaglandin endoperoxides which are utilized to form PGX.
Journal ArticleDOI
Release of prostaglandins and thromboxane into the coronary circulation in patients with ischemic heart disease.
TL;DR: The data suggest that local thromboxane release is associated with recent episodes of angina in patients with unstable angina pectoris, but whether this release is a cause or an effect is not yet known.
Journal ArticleDOI
Coronary tone modulation: formation and actions of prostaglandins, endoperoxides, and thromboxanes.
TL;DR: Coronary tone, and possible spasm, in ischemic myocardial zones may be influenced markedly by interplay between prostaglandins, endoperoxides, and thromboxane formed by platelets on the one hand, and endoperoxide products synthesized endogenously in the coronary arteries on the other.
Journal ArticleDOI
Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature.
TL;DR: Data indicate that thromboxane A, is produced during pacing-induced myocardial ischemia and could alter regional coronary blood flow.
Journal ArticleDOI
The hemostatic mechanism after open-heart surgery. II. Frequency of abnormal platelet functions during and after extracorporeal circulation.
Rajalaxmi McKenna,Rajalaxmi McKenna,Fedor Bachmann,Fedor Bachmann,Barbara Whittaker,Barbara Whittaker,James R. Gilson,James R. Gilson,Milton Weinberg,Milton Weinberg +9 more
TL;DR: Dilution of the patient's own platelets by nonviable platelets contained in 3-day-old transfused ACD blood and the production of a refractory state of the customer's circulating platelets to ADP induced aggregation played a significant role in the development of platelet function abnormalities during extracorporeal circulation.