Time to revise the paradigm of hantavirus syndromes? Hantavirus pulmonary syndrome caused by European hantavirus
TLDR
Three cases of severe European Puumala hantavirus infection that meet the HPS case definition are presented and are considered as a cause of acute respiratory distress in all endemic areas worldwide.Abstract:
Hantaviruses have previously been recognised to cause two separate syndromes: hemorrhagic fever with renal syndrome in Eurasia, and hantavirus pulmonary syndrome (HPS) in the Americas. However, increasing evidence suggests that this dichotomy is no longer fruitful when recognising human hantavirus disease and understanding the pathogenesis. Herein are presented three cases of severe European Puumala hantavirus infection that meet the HPS case definition. The clinical and pathological findings were similar to those found in American hantavirus patients. Consequently, hantavirus infection should be considered as a cause of acute respiratory distress in all endemic areas worldwide.read more
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Uncovering the mysteries of hantavirus infections
Antti Vaheri,Tomas Strandin,Jussi Hepojoki,Tarja Sironen,Heikki Henttonen,Satu Mäkelä,Jukka Mustonen +6 more
TL;DR: The basic molecular properties and cell biology of hantaviruses are discussed and an overview of virus-induced pathology, in particular vascular leakage and immunopathology is offered.
Journal ArticleDOI
Hantavirus infections in Europe and their impact on public health.
Antti Vaheri,Antti Vaheri,Heikki Henttonen,Liina Voutilainen,Liina Voutilainen,Jukka Mustonen,Tarja Sironen,Olli Vapalahti,Olli Vapalahti +8 more
TL;DR: It is concluded that hantaviruses have a significant impact on public health in Europe and no vaccine or specific therapy is in general use in Europe.
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β2 integrin mediates hantavirus-induced release of neutrophil extracellular traps
Martin Raftery,Pritesh Lalwani,Ellen Krautkrӓmer,Thorsten Peters,Karin Scharffetter-Kochanek,Renate Krüger,Jörg Hofmann,Karl Seeger,Detlev H. Krüger,Günther Schönrich +9 more
TL;DR: β2 Integrin–mediated systemic release of neutrophil extracellular traps is a novel mechanism of immunopathology associated with hantavirus infection.
Journal ArticleDOI
Epidemiology of Hantavirus infections in humans: a comprehensive, global overview.
TL;DR: Prevention may be enhanced by host-reservoir control and human exposure prophylaxis interventions, which likely have led to a dramatic reduction of human cases in China over the past decades; vaccination may also play a role in the future.
Journal ArticleDOI
Hantavirus infection: an emerging infectious disease causing acute renal failure
TL;DR: The picture of strict organ tropism is changing and reports of pulmonary findings and nonrenal manifestations in infections with Old World hantaviruses are increasing, however, the overall symptoms-vascular alterations and leakage-that are responsible for organ failure are characteristic for all diseases caused by hantviruses.
References
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Sundsfjord A,Sjöberg L,Hegstad K +2 more
Journal ArticleDOI
Hantavirus Pulmonary Syndrome: A Clinical Description of 17 Patients with a Newly Recognized Disease
Jeffrey S. Duchin,Frederick Koster,Clarence J. Peters,Gary L. Simpson,Gary L. Simpson,Bruce Tempest,Sherif R. Zaki,Thomas G. Ksiazek,Pierre E. Rollin,Stuart T. Nichol,Edith T. Umland,Ronald L. Moolenaar,Susan E. Reef,Kurt B. Nolte,Margaret M. Gallaher,Jay C. Butler,Robert F. Breiman +16 more
TL;DR: Clinical, laboratory, and autopsy data on the first 17 persons with confirmed infection from this newly recognized strain of hantavirus identified as the cause of an outbreak of severe respiratory illness in the southwestern United States are analyzed.
Journal Article
Hantavirus Pulmonary Syndrome: Pathogenesis of an Emerging Infectious Disease
Sherif R. Zaki,Patricia W. Greer,L M Coffield,Cynthia S. Goldsmith,Kurt B. Nolte,Kathy Foucar,Richard M. Feddersen,Ross E. Zumwalt,Gayle L. Miller,Ali S. Khan,Pierre E. Rollin,Thomas G. Ksiazek,Stuart T. Nichol,Brian W. J. Mahy,Clarence J. Peters +14 more
TL;DR: Pulmonary histopathological features were similar in most of the fatal HPS cases and consisted of an interstitial pneumonitis with a variable mononuclear cell infiltrate, edema, and focal hyaline membranes, however, pulmonary features were significantly different and included diffuse alveolar damage and variable degrees of severe air space disorganization.
Journal ArticleDOI
Hantavirus infections in Europe.
Olli Vapalahti,Jukka Mustonen,Åke Lundkvist,Heikki Henttonen,Alexander Plyusnin,Alexander Plyusnin,Antti Vaheri,Antti Vaheri +7 more
TL;DR: There are few available data about the clinical picture of confirmed Saaremaa infections, but epidemiological evidence suggests that it is less pathogenic than Dobrava, and that SaareMAa infections are more similar to nephropathia epidemica caused by Puumala.
Book ChapterDOI
Hantavirus infections in Europe
TL;DR: There are few available data about the clinical picture of confirmed Saaremaa infections, but epidemiological evidence suggests that it is less pathogenic than Dobrava, and that SaareMAa infections are more similar to nephropathia epidemica caused by Puumala.