Total Syntheses of Tanshinone-I, Tanshinone-II and Cryptotanshinone
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In this article, the effect of substituents for orientation phenomena can be considered to be of electronic nature, and preliminary accounts for the Diels-Alder reaction of methoxybenzoquinone revealed that the effect on orientation properties can be assumed to be electronic.Abstract:
Total syntheses of tanshinone-II (II) and cryptotanshinone (III) from 3-methylbenzofuran-4, 7-quinone (X) and 6,6-dimethyl-l-vinylcyclohexene (IX), and of tanshinone-I (I) from quinone X and o-methylstyrene (XVIII) are described. Preliminary accounts for the Diels-Alder reaction of methoxybenzoquinone revealed that the effect of substituents for orientation phenomena can be considered to be of electronic nature.read more
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Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents
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Natural products possessing protein tyrosine phosphatase 1B （PTP1B） inhibitory activity found in the last decades
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Total synthesis of dan shen diterpenoid quinones
TL;DR: A photochemical aromatic annulation strategy provides efficient synthetic routes to the diterpenoid quinones (+)-danshexinkun A, danshex-inkun B, Danshexin-C, (−)-dihydrotanshinone I, and tansinone I.
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Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors
TL;DR: Cryptotanshinone and its simplified analogues were synthesized via SmI2 promoted radical cyclization to construct the furan ring and were identified as effective inhibitors of dual specificity protein phosphatase CDC25B and inhibited growth in A-549 human lung cancer cell line.
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Total Synthesis of Neo‐Tanshinlactones through a Cascade Benzannulation‐Lactonization as the Key Step
TL;DR: In this article, a cascade annulation-lactonization of phthalides with α-carboxyfurylacrylates in the presence of lithium hexamethyldisilazide (LiHMDS) provides both convergent and semiconvergent regioselective syntheses of neo-tanshinlactones in moderate yields.
References
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Diels‐Alder reactions II: The Reaction Mechanism
TL;DR: The possible mechanisms of the preparatively so productive Diels-Alder reactions are discussed critically on the basis of experimental data as discussed by the authors, although most of the facts can be explained readily by a synchronous mechanism, a number of problems remains.
Journal ArticleDOI
Reaktionen mit Nitrosodisulfonat, V. Mitteil.): Über die Bildung von Naphtochinonen†
Hans‐Joachim Teuber,Norbert Götz +1 more
TL;DR: In this paper, ausnahmsweise werden hier p- und o-Chinon nebeneinander gebildet 26-Dioxy-naphthalin wird nicht zu amphi-Naphthochinon dehydriert, sondern zu 6-Oxynaphthocinon-(12) oxydiert 2-Oxy-anthracen verhalt sich wie Naphthol-(2); 8-OXY-chinolin geht in Chinolinch
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A perturbational MO method applied to diels-alder reactions with unsymmetrical dienes and dienophiles
J. Feuer,W.C. Herndon,L.H. Hall +2 more
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