Journal ArticleDOI
Total synthesis of halichondrin B and norhalichondrin B
Thomas Daniel Aicher,Keith R. Buszek,Francis G. Fang,Craig J. Forsyth,Sun Ho Jung,Yoshito Kishi,Michael C. Matelich,Paul Michael Scola,Denice M. Spero,Suk Kyoon Yoon +9 more
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This article is published in Journal of the American Chemical Society.The article was published on 1992-04-01. It has received 347 citations till now. The article focuses on the topics: Halichondrin B & Total synthesis.read more
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A historical overview of natural products in drug discovery.
TL;DR: A review of historically significant bioactive marine and terrestrial natural products, their use in folklore and dereplication techniques to rapidly facilitate their discovery, and a discussion of how natural product chemistry has resulted in the identification of many drug candidates are highlighted.
Journal ArticleDOI
Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential
TL;DR: The ecology of sponge-microbe associations is examined, including the establishment and maintenance of these sometimes intimate partnerships, the varied nature of the interactions (ranging from mutualism to host-pathogen relationships), and the broad-scale patterns of symbiont distribution.
Journal ArticleDOI
Drug development from marine natural products
Tadeusz F. Molinski,Doralyn S. Dalisay,Sarah L. Lievens,Sarah L. Lievens,Jonel P. Saludes,Jonel P. Saludes +5 more
TL;DR: The history of drug discovery from marine natural products is reviewed, and by describing selected examples, the factors that contribute to new discoveries and the difficulties associated with translating marine-derived compounds into clinical trials are examined.
Journal ArticleDOI
Natural products to drugs: natural product derived compounds in clinical trials
Mark S. Butler,Mark S. Butler +1 more
TL;DR: Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural products for which clinical trials have been halted or discontinued since 2005.
Journal ArticleDOI
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
David J. Newman,Gordon M. Cragg +1 more
TL;DR: There are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases.
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Murray J. Towle,Kathleen A. Salvato,Jacqueline Budrow,Bruce F. Wels,Galina Kuznetsov,Kimberley K. Aalfs,Susan Welsh,Wanjun Zheng,Boris M. Seletsky,Monica Palme,Gregory J. Habgood,Lori A. Singer,Lucian Dipietro,Yuan Wang,Jack J. Chen,David A. Quincy,Ashley Davis,Kentaro Yoshimatsu,Yoshito Kishi,Melvin J. Yu,Bruce A. Littlefield +20 more