Tracking adipogenesis during white adipose tissue development, expansion and regeneration
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TLDR
The developed system for the inducible, permanent labeling of mature adipocytes that is called the AdipoChaser mouse and results highlight the extensive differences in adipogenic potential in various fat depots.Abstract:
White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HFD) feeding and cold exposure. During cold-induced 'browning' of subcutaneous fat, most 'beige' adipocytes stem from de novo-differentiated adipocytes. During HFD feeding, epididymal fat initiates adipogenesis after 4 weeks, whereas subcutaneous fat undergoes hypertrophy for a period of up to 12 weeks. Gonadal fat develops postnatally, whereas subcutaneous fat develops between embryonic days 14 and 18. Our results highlight the extensive differences in adipogenic potential in various fat depots.read more
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References
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Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
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PRDM16 controls a brown fat/skeletal muscle switch
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