Tract-defined regional white matter hyperintensities and memory
Batool Rizvi,Patrick J. Lao,Juliet Colon,Christiane Hale,Kay C. Igwe,Atul Narkhede,Mariana Budge,Jennifer J. Manly,Nicole Schupf,Adam M. Brickman +9 more
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TLDR
White matter hyperintensity volume in association and projection tracts was related to memory in older adults and the relationship of WMH volumes with cognition was specific to memory, and not to a global cognition measure that excluded memory.About:
This article is published in NeuroImage: Clinical.The article was published on 2020-01-01 and is currently open access. It has received 26 citations till now. The article focuses on the topics: Hyperintensity & Cognitive decline.read more
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White matter hyperintensity topography in Alzheimer's disease and links to cognition.
Antoine Garnier-Crussard,Antoine Garnier-Crussard,Salma Bougacha,Miranka Wirth,Sophie Dautricourt,Siya Sherif,Brigitte Landeau,Julie Gonneaud,Robin de Flores,Vincent de la Sayette,Denis Vivien,Pierre Krolak-Salmon,Pierre Krolak-Salmon,Gaël Chételat +13 more
TL;DR: In this article, a cross-sectional association between regional WMH volume and cognition was assessed within each group, controlling for cerebral amyloid burden, global cortical atrophy, and hippocampal atrophy.
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White matter hyperintensities are associated with grey matter atrophy and cognitive decline in Alzheimer's disease and frontotemporal dementia
TL;DR: In this paper , the impact of WMHs on grey matter atrophy and cognition in normal aging (n = 571), mild cognitive impairment (MCI, n = 551), Alzheimer's dementia (AD, N = 212), fronto-temporal dementia (FTD, N= 125), and Parkinson's disease (PD, n= 271).
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Free water: A marker of age-related modifications of the cingulum white matter and its association with cognitive decline.
Manon Edde,Guillaume Theaud,François Rheault,Bixente Dilharreguy,Catherine Helmer,Jean-François Dartigues,Hélène Amieva,Michèle Allard,Maxime Descoteaux,Gwénaëlle Catheline,Gwénaëlle Catheline +10 more
TL;DR: It is observed that free water elimination increased the ability of conventional DTI measures to detect associations between tissue diffusion measures of the cingulum and changes in verbal fluency in older individuals, suggesting thatfree water itself could be a relevant marker for age-related cingula white matter modifications and cognitive decline.
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The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance.
TL;DR: In this paper, structural equation models were used to test the effect of vascular risk factors on executive function and executive function was found to be negatively influenced by increased systolic blood pressure and white matter hyperintensity.
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The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance
TL;DR: It is suggested that aging brings about increases in both BP and WMH burden, which may be involved in the degradation of white matter connectivity and in turn, negatively impact executive functions as the authors age.
References
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