Evan Fletcher

TL;DR: Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development, suggesting early memory deficit associated with the primary disease factors.

TL;DR: The frontal lobes are most severely affected by SIVD, and WMHs are more abundant in the frontal region, regardless of where in the brain these WMH's are located, they are associated with frontal hypometabolism and executive dysfunction.

TL;DR: In this paper, MRI segmentation and mapping techniques were used to assess evidence in support of categorical distinctions between periventricular white matter hyperintensities (PVWMH) and deep WMH (DWMH).

TL;DR: Differences in white matter hyperintensities (WMH) associated with increasing cognitive impairment appear related to both extent and spatial location, and multiple regression analysis of regional WMH, vascular risk factors, and diagnosis suggest that these spatial differences may result from the additive effects of vascular and degenerative injury.

TL;DR: It is suggested that subtle vascular brain injury develops insidiously during life, with discernible effects even in young adults, and the need for early and optimum control of blood pressure is emphasised.