Transforming growth factor-beta trans-modulates the expression of colony stimulating factor receptors on murine hematopoietic progenitor cell lines
Sten Eirik W. Jacobsen,Francis W. Ruscetti,Claire M. Dubois,John Lee,Thomas C. Boone,Jonathan R. Keller +5 more
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The data suggest that the downregulation of the growth of hematopoietic progenitor cells by TGF-beta involves reducing the cell surface expression on growth factor receptors.About:
This article is published in Blood.The article was published on 1991-04-15 and is currently open access. It has received 86 citations till now. The article focuses on the topics: Growth factor receptor & Growth factor receptor inhibitor.read more
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Hematopoietic stem cell: self-renewal versus differentiation
Jun Seita,Irving L. Weissman +1 more
TL;DR: This review focuses on the hierarchical structure of the hematopoietic system, the current understanding of microenvironment and molecular cues regulating self‐renewal and differentiation of adult HSCs, and the currently emerging systems approaches to understand HSC biology.
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Processing of transforming growth factor beta 1 precursor by human furin convertase.
TL;DR: Evidence is provided that in experimental systems the TGFβ1 precursor is efficiently and correctly processed by human furin thus permitting release of the biologically active peptide.
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Signaling pathways governing stem-cell fate
TL;DR: The focus of this review is to highlight some of the most recent developments concerning signaling pathways governing HSC fate, including Notch, Wingless-type (Wnt), Sonic hedgehog (Shh), and Smad pathways.
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Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis
TL;DR: A large number of molecules involved in the regulation of hematopoiesis include soluble cytokines and growth factors, cell-cell interaction molecules, and extracellular matrix components, which provide a multifunctional scaffolding specific for each tissue.
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Transforming growth factor beta 1 directly and reversibly inhibits the initial cell divisions of long-term repopulating hematopoietic stem cells.
TL;DR: It is shown that the continuous presence of TGF-beta 1 directly inhibits the cell division of essentially all low Ho/Rh cells during their 0 to 5th cell division in vitro, which must directly inhibit the proliferation of LTR-HSC contained within these low Ho-Rh cells.
References
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The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
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Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth.
John H. Kehrl,Lalage M. Wakefield,Anita B. Roberts,Sonia B. Jakowlew,Melchor Alvarez-Mon,Rik Derynck,Michael B. Sporn,Anthony S. Fauci +7 more
TL;DR: TGF-beta may be an important antigen-nonspecific regulator of human T cell proliferation, and important in T cell interaction with other cell types whose cellular functions are modulated by TGF- beta.
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Growth factors from murine sarcoma virus-transformed cells.
J E De Larco,George J. Todaro +1 more
TL;DR: The sarcoma growth factors are a new class of polypeptide tropic factors that confer on fibroblasts in vitro properties associated with the transformed phenotype that are heat-stable, trypsin-sensitive, and active in nanogram quantities when tested for growth stimulation of untransformed rat and mouse fibro Blasts.
Journal Article
Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes.
John H. Kehrl,Anita B. Roberts,Lalage M. Wakefield,Sonia B. Jakowlew,Michael B. Sporn,Anthony S. Fauci +5 more
TL;DR: Data is presented that support a role for transforming growth factor (TGF)-beta in this regulatory process that limits B lymphocyte proliferation and ultimate differentiation and it was demonstrated that B lymphocytes secrete TGF-beta.
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Growth of factor-dependent hemopoietic precursor cell lines.
TL;DR: It is suggested that the cell lines represent a self-renewing population of cells ancestral to GM colony- forming cells, which may be responding to a hitherto unrecognized regulator.