Journal ArticleDOI
Transglucosylation potential of six sucrose phosphorylases toward different classes of acceptors
TLDR
Improving the affinity for alternative acceptors by means of enzyme engineering will be a major challenge for the commercial exploitation of the transglucosylation potential of sucrose phosphorylase.About:
This article is published in Carbohydrate Research.The article was published on 2011-09-27. It has received 59 citations till now. The article focuses on the topics: Sucrose phosphorylase & Leuconostoc mesenteroides.read more
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Biotechnological advances in UDP-sugar based glycosylation of small molecules
TL;DR: This review gives an extensive overview of the recently developed in vivo production processes using UGTs and discusses the major routes towards UDP-sugar formation, including the use of interconverting enzymes and glycorandomization for the production of unusual or new-to-nature glycosides.
Journal ArticleDOI
Enzymatic synthesis using glycoside phosphorylases
Ellis C. O’Neill,Robert A. Field +1 more
TL;DR: A review of reported phosphorylase enzymes and the glycoside products that they have been used to synthesise can be found in this paper, where a wide range of these enzymes has been reported of late, displaying a range of preferences for sugar donors, acceptors and glycosidic linkages.
Journal ArticleDOI
Role of Glycoside Phosphorylases in Mannose Foraging by Human Gut Bacteria
Simon Ladevèze,Simon Ladevèze,Laurence Tarquis,Laurence Tarquis,Davide A. Cecchini,Davide A. Cecchini,Juliette Bercovici,Juliette Bercovici,Isabelle André,Isabelle André,Christopher M. Topham,Christopher M. Topham,Sandrine Morel,Sandrine Morel,Elisabeth Laville,Elisabeth Laville,Pierre Monsan,Pierre Monsan,Vincent Lombard,Bernard Henrissat,Gabrielle Potocki-Véronèse,Gabrielle Potocki-Véronèse +21 more
TL;DR: The use of GH130 inhibitors as therapeutic agents or functional foods could thus be considered as an innovative strategy to inhibit N-glycan degradation, with the ultimate goal of protecting, or restoring, the epithelial barrier.
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Enzymatic modification enhances the protective activity of citrus flavonoids against alcohol-induced liver disease
TL;DR: Results indicate that although the administration of CFs can alleviate ALD through preventing excessive lipid formation, protecting the antioxidant system and suppressing induction of inflammation in hepatocytes, their effectiveness can be further improved by glycosylation and de-rhamnosylation.
Journal ArticleDOI
Sucrose Phosphorylase and Related Enzymes in Glycoside Hydrolase Family 13: Discovery, Application and Engineering.
Jorick Franceus,Tom Desmet +1 more
TL;DR: An overview of the progress that has been made in the understanding and exploitation of sucrose phosphorylases and related enzymes over the past ten years is provided.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics
Brandi L. Cantarel,Pedro M. Coutinho,Corinne Rancurel,Thomas Bernard,Vincent Lombard,Bernard Henrissat +5 more
TL;DR: The Carbohydrate-Active Enzyme (CAZy) database is a knowledge-based resource specialized in the enzymes that build and breakdown complex carbohydrates and glycoconjugates and has been used to improve the quality of functional predictions of a number genome projects by providing expert annotation.
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A classification of glycosyl hydrolases based on amino acid sequence similarities.
TL;DR: With the steady increase in sequence and structural data, it is suggested that the enzyme classification system should perhaps be revised.
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Updating the sequence-based classification of glycosyl hydrolases.
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Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. Neslihan Gürsoy,Simon Benita +1 more
TL;DR: Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds as discussed by the authors.