Transport of Ornithine and Citrulline across the Mitochondrial Membrane
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TLDR
The driving force for entry of ornithine+ is concluded to be a negative-inside transmembrane potential produced when proton-conducting anions enter mitochondria to relieve the alkaline-inside pH gradient generated by electron transport.About:
This article is published in Journal of Biological Chemistry.The article was published on 1973-01-25 and is currently open access. It has received 196 citations till now. The article focuses on the topics: Ornithine transcarbamylase & Ornithine.read more
Citations
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Comparative properties of arginases.
TL;DR: An outline of the current state of arginase research is presented by giving a comparative overview ofArginases and their associated properties by way of comparison with previous work.
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The regulation of amino acid transport in animal cells.
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Biochemistry of Mitochondrial Nitric-oxide Synthase *
TL;DR: The mitochondria generation of nitric oxide by mitochondria is catalyzed by a constitutive, mitochondrial nitric-oxide synthase (mtNOS), which was identified as brain NOSα by various methods and has two post-translational modifications: acylation with myristic acid and phosphorylation at the C terminus.
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Optimization of conditions for the colorimetric determination of citrulline, using diacetyl monoxime
TL;DR: A method is described for colorimetric determination of citrulline following deproteinization, depending upon the reaction with diacetyl monoxime in the presence of sulfuric and phosphoric acids, with diminished heating time compared with existing procedures.
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Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter.
Jose A. Camacho,Cassandra Obie,Barbara Biery,Barbara K. Goodman,Chien-An Andy Hu,Shlomo Almashanu,Gary Steel,Robin Casey,Marie Lambert,Grant A. Mitchell,David Valle +10 more
TL;DR: The results show that ORNT1 encodes the mitochondrial ornithine transporter involved in UC function and is defective in HHH syndrome.
References
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Enzymatic properties of the inner and outer membranes of rat liver mitochondria
TL;DR: The inner membrane-matrix fraction retained a high degree of morphological and biochemical integrity and exhibited a high respiratory rate and respiratory control when assayed in a sucrose-mannitol medium containing EDTA.
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A simple ultraviolet spectrophotometric method for the determination of protein.
TL;DR: An ultraviolet spectrophotometric method for the determination of proteins has advantages over other methods in simplicity, rapidity, accuracy, specificity, and sensitivity, but is not useful for thedetermination of protein in urine.
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Intracellular distribution of enzymes; the oxidation of octanoic acid by rat liver fractions.
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ULTRASTRUCTURAL BASES FOR METABOLICALLY LINKED MECHANICAL ACTIVITY IN MITOCHONDRIA I. Reversible Ultrastructural Changes with Change in Metabolic Steady State in Isolated Liver Mitochondria
TL;DR: Isolated mitochondria were found to oscillate between the orthodox and condensed conformations during reversible transitions between State III and State IV, representing an ultrastructural basis for metabolically linked mechanical activity in tightly coupled mitochondria.
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The submitochondrial localization of monoamine oxidase. An enzymatic marker for the outer membrane of rat liver mitochondria.
TL;DR: Digitonin treatment released more monoamine oxidase than cytochrome oxidase from sonic particles, thus indicating that digitonin preferentially degrades the outer mitochondrial membrane.