Journal ArticleDOI
Treatment of restless legs syndrome and periodic movements during sleep with L‐dopa: A double‐blind, controlled study
TLDR
Observations support the hypothesis that RLS and PMS are two manifestations of the same central sensorimotor disorder.Abstract:
Six patients with restless legs syndrome (RLS) and periodic movements during sleep (PMS) received placebo or L-dopa in a double-blind study. We recorded patients for 36 consecutive hours in the sleep laboratory during a baseline investigation and at the end of each treatment period. Daily evening questionnaires and a suggested immobilization test (SIT) performed at bedtime on each recording night documented the effect of L-dopa in RLS. A nocturnal EMG recording of the anterior tibialis muscles revealed the effect of L-dopa on PMS. L-Dopa proved effective in treating both RLS and PMS. Although not present in every patient, leg movements recorded during the SIT exhibited a clear periodicity. These observations support the hypothesis that RLS and PMS are two manifestations of the same central sensorimotor disorder.read more
Citations
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Journal ArticleDOI
Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health.
Richard P. Allen,Daniel L. Picchietti,Wayne A. Hening,Claudia Trenkwalder,Arthur S. Walters,Jacques Montplaisi +5 more
TL;DR: Modification of the criteria for the diagnosis of restless legs syndrome is modified to better reflect that increased body of knowledge, as well as to clarify slight confusion with the wording of the original criteria.
Journal ArticleDOI
Toward a better definition of the restless legs syndrome
Arthur S. Walters,Michael S. Aldrich,Richard P. Allen,Sonia Ancoli-Israel,David W. Buchholz,Sudhansu Chokroverty,Giorgio Coccagna,Christopher J. Earley,Bruce L. Ehrenberg,T. G. Feest,Wayne A. Hening,Neil B. Kavey,Gilles Lavigne,Joseph F. Lipinski,Elio Lugaresi,Pasquale Montagna,Jacques Montplaisir,Sarah S. Mosko,Wolfgang H. Oertel,Daniel L. Picchietti,Thomas Pollmächer,Renata Shafor,Robert C. Smith,Wenche Telstad,C. Trenkwalder,C. Trenkwalder,Christian von Scheele,J. Catesby Ware,Marco Zucconi +28 more
TL;DR: A large International Restless Legs Syndrome (RLS) Study Group has been formed as discussed by the authors, which has taken upon itself the role of definig the clinical features of the RLS, including sleep disturbance, periodic limb movements in sleep and similar involuntary movements while awake, a normal neurological examination in the idiopathic from, a tendency for the symptoms to be worse in middle to older age, and a family history suggestive of an autosomal dominant mode of inheritance.
Journal ArticleDOI
Screening for dementia with the Memory Impairment Screen
Herman Buschke,Gail Kuslansky,Mindy J. Katz,Walter F. Stewart,Martin J. Sliwinski,Haftan Eckholdt,Richard B. Lipton +6 more
TL;DR: The Memory Impairment Screen provides efficient, reliable, and valid screening for AD and other dementias and presents normative data for use in settings with different base rates (prevalences) of AD and dementia.
Journal ArticleDOI
Restless legs syndrome
TL;DR: Patients with restless legs syndrome (RLS) should be evaluated for iron deficiency anemia; iron replacement in deficient patients may lead to a resolution of symptoms or may reduce the severity of their symptoms.
Journal ArticleDOI
Restless legs syndrome: a review of clinical and pathophysiologic features.
TL;DR: This review of RLS covers history, diagnosis, morbidity of sleep disturbance, relation to periodic limb movements in both sleep and waking, secondary causes, severity assessment methods, phenotypes for possible genetic patterns, epidemiology, pathophysiology, and medical treatmentconsiderations.
References
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Journal ArticleDOI
A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects.
TL;DR: Techniques of recording, scoring, and doubtful records are carefully considered, and Recommendations for abbreviations, types of pictorial representation, order of polygraphic tracings are suggested.
Journal ArticleDOI
Restless legs syndrome and periodic movements in sleep: physiopathology and treatment with L-dopa.
TL;DR: The hypothesis that RLS and PMS may both result from reduced dopaminergic activity in the CNS, perhaps resulting from decreased sensibility of postsynaptic receptors, is raised.
Journal ArticleDOI
Familial restless legs with periodic movements in sleep Electrophysiologic, biochemical, and pharmacologic study
TL;DR: In three subjects, the diagnosis of restless legs syndrome was confirmed by all-night sleep recordings and concomitant EMG, and Clonazepam effectively controlled restless legs in the propositus and his mother.
Journal ArticleDOI
Restless legs syndrome treatment with dopaminergic drugs.
TL;DR: These dopaminergic drugs decreased the times of waking up and staying awake periods at a statistically significant level (p changed between 0.025 and 0.01, t test) compared with placebo.
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