Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease.
TLDR
Two new lanostane-type triterpenes, lucidumol A and ganoderic acid beta, were isolated from the spores of Ganoderma (G.) lucidum and showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microM.Abstract:
Two new lanostane-type triterpenes, lucidumol A and ganoderic acid beta, were isolated from the spores of Ganoderma (G) lucidum, together with a new natural one and seven that were known The structures of the new triterpenes were determined as (24S)-24,25-dihydroxylanost-8-ene-3,7-dione and 3 beta,7 beta-dihydroxy-11,15-dioxolanosta-8,24(E)-dien-26-oic acid, respectively, by chemical and spectroscopic means The quantitative analyses of 5 fruiting bodies, antlered form and spores of G lucidum were performed by high performance liquid chromatography and demonstrated that ganoderic alcohol and acid contents were quite high in the spore Of the compound isolated, ganoderic acid beta, (24S)-lanosta-7,9(11)-diene-3 beta,24,25-triol (called lucidumol B), ganodermanondiol, ganodermanontriol and ganolucidic acid A showed significant anti-human immunodeficiency virus (anti-HIV)-1 protease activity with IC50 values of 20-90 microMread more
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Ganoderma lucidum and its pharmaceutically active compounds
TL;DR: The most important pharmacologically active constituents of G. lucidum are triterpenoids and polysaccharides, especially beta-d-glucans, have been known to possess anti-tumor effects through immunomodulation and anti-angiogenesis.
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Ganoderma lucidum: a potent pharmacological macrofungus.
TL;DR: Ganoderma lucidum has now become recognized as an alternative adjuvant in the treatment of leukemia, carcinoma, hepatitis and diabetes, and playing a significant role in various therapeutic applications.
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From 2000years of Ganoderma lucidum to recent developments in nutraceuticals.
Karen S. Bishop,Chi H.J. Kao,Yuanye Xu,Marcus P. Glucina,R. Russell M. Paterson,Lynnette R. Ferguson +5 more
TL;DR: A review of G. lucidum over the past 2000 years from prized ancient "herbal" remedy to its use in nutraceuticals and to the establishment of a 2.5 billion $ (US) industry is presented.