Journal ArticleDOI
Trophic factors and neuronal survival
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This article is published in Neuron.The article was published on 1989-06-01. It has received 1623 citations till now. The article focuses on the topics: Trophic level.read more
Citations
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Coordinated expression of messenger RNAs for nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 in the rat hippocampus following transient forebrain ischemia
TL;DR: The results suggest that nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 genes are differentially regulated and that each of their gene products may play different roles in the central nervous system under pathophysiological conditions.
Journal ArticleDOI
Degenerative and regenerative responses of injured neurons in the central nervous system of adult mammals
Albert J. Aguayo,Michael Rasminsky,Garth M. Bray,S. Carbonetto,Lisa McKerracher,María Paz Villegas-Pérez,Manuel Vidal-Sanz,D. A. Carter +7 more
TL;DR: Experimental manipulations of the non-neuronal environment of injured RGCs enhance neuronal survival and make possible a lengthy axonal regeneration that restores functional connections with the superior colliculus, suggesting that injured nerve cells in the mature central nervous system (CNS) are strongly influenced by interactions with components of their immediate environment as well as their targets.
Journal ArticleDOI
Dependence of Kidney Morphogenesis on the Expression of Nerve Growth Factor Receptor
Hannu Sariola,Mart Saarma,Kirsi Sainio,Urmas Arumäe,Jaan Palgi,Anne Vaahtokari,Irma Thesleff,Alexander Karavanov +7 more
TL;DR: Nerve growth factor receptor (NGFR) serves as the binding site for the neurotrophic growth factors and is required not only for development of the nervous system, but also for differentiation of the kidney tubules.
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The survival of developing neurons: A review of afferent control
TL;DR: It is argued that targets and afferents may have equivalent roles and interact in the control of neuron numbers during development of the vertebrate nervous system.
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Differential effects of NGF, FGF, EGF, cAMP, and dexamethasone on neurite outgrowth and sodium channel expression in PC12 cells.
JD Pollock,M Krempin,B Rudy +2 more
TL;DR: Although the increase in sodium channel expression induced by NGF and basic FGF parallels the changes in morphology that lead to neurite outgrowth, it clearly does not depend on them, and shows that different aspects of neuronal differentiation might be independently regulated by the microenvironment.
References
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Journal ArticleDOI
Purification of a new neurotrophic factor from mammalian brain.
TL;DR: This factor is the first neurotrophic factor to be purified since NGF, from which it is clearly distinguished because it has different antigenic and functional properties.
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Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
TL;DR: It is suggested that fimbrial transections resulted in retrograde degeneration of cholinergic septo-hippocampal neurons and that NGF treatment strongly attenuated this lesion-induced degeneration.
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Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection
Lawrence R. Williams,Silvio Varon,Gary M. Peterson,Klas Wictorin,Walter Fischer,Anders Björklund,Fred H. Gage +6 more
TL;DR: It is reported here that NGF treatment significantly reduces both the total neuronal and cholinergic neuronal death found 2 weeks after fimbria fornix transection; there was a sparing of 50% of the neurons in the MS and essentially 100% of those in the VDB that otherwise would have died.