Journal ArticleDOI
Trophic factors and neuronal survival
About:
This article is published in Neuron.The article was published on 1989-06-01. It has received 1623 citations till now. The article focuses on the topics: Trophic level.read more
Citations
More filters
Journal ArticleDOI
Programmed Cell Death in Animal Development
TL;DR: Because of the limited number of references allowed, the authors were unable to cite many important papers; they apologize to their authors.
Journal ArticleDOI
Mechanisms and Functions of Cell Death
TL;DR: Cell Death During the Metamorphosis of Moths, Cells That Develop Improperly, and Mechanisms That Kill Cells.
Journal ArticleDOI
Neurotrophin regulation of neural circuit development and function
Hyungju Park,Mu-ming Poo +1 more
TL;DR: Some of the recent progress in understanding the cellular and molecular mechanisms underlying neurotrophin regulation of neural circuits are summarized in this Review.
Journal ArticleDOI
Programmed cell death and the control of cell survival: lessons from the nervous system
TL;DR: This neurotrophic strategy for the regulation of neuronal numbers may be only one example of a general mechanism that helps to regulate the numbers of many other vertebrate cell types, which also require signals from other cells to survive.
References
More filters
Journal ArticleDOI
Purification of a new neurotrophic factor from mammalian brain.
TL;DR: This factor is the first neurotrophic factor to be purified since NGF, from which it is clearly distinguished because it has different antigenic and functional properties.
Journal ArticleDOI
Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
TL;DR: It is suggested that fimbrial transections resulted in retrograde degeneration of cholinergic septo-hippocampal neurons and that NGF treatment strongly attenuated this lesion-induced degeneration.
Journal ArticleDOI
Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection
Lawrence R. Williams,Silvio Varon,Gary M. Peterson,Klas Wictorin,Walter Fischer,Anders Björklund,Fred H. Gage +6 more
TL;DR: It is reported here that NGF treatment significantly reduces both the total neuronal and cholinergic neuronal death found 2 weeks after fimbria fornix transection; there was a sparing of 50% of the neurons in the MS and essentially 100% of those in the VDB that otherwise would have died.