Tumor necrosis factor identified in multiple sclerosis brain.
Reads0
Chats0
TLDR
The presence of TNF in MS lesions suggests a significant role for cytokines and the immune response in disease progression and is not made in Alzheimer's disease or normal brain tissue.Abstract:
Frozen brain specimens from patients with multiple sclerosis (MS) and other neurologic diseases were analyzed using immunocytochemical techniques for the presence of TNF In brain lesions in MS, and subacute sclerosing panencephalitis, TNF+ cells were demonstrated At the lesion site in MS, TNF+ staining is associated with both astrocytes and macrophages These observations were not made in Alzheimer's disease or normal brain tissue The presence of TNF in MS lesions suggests a significant role for cytokines and the immune response in disease progressionread more
Citations
More filters
Journal ArticleDOI
Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination.
Claudia F. Lucchinetti,Wolfgang Brück,Joseph E. Parisi,Bernd W. Scheithauer,Moses Rodriguez,Hans Lassmann +5 more
TL;DR: At a given time point of the disease, the patterns of demyelination were heterogeneous between patients, but were homogenous within multiple active lesions from the same patient, suggesting that MS may be a disease with heterogeneous pathogenetic mechanisms.
Journal ArticleDOI
Molecular profile of reactive astrocytes—Implications for their role in neurologic disease
Michael Eddleston,Lennart Mucke +1 more
TL;DR: A summary of molecules whose levels of expression differentiate activated from resting astrocytes is provided and it becomes apparent that reactive astroCytes may benefit the injured nervous system by participating in diverse biological processes.
Journal ArticleDOI
Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion.
Michael Barnett,John W. Prineas +1 more
TL;DR: Clinical and pathological findings in 12 patients with relapsing and remitting multiple sclerosis, who died during or shortly after the onset of a relapse, raise the possibility of some novel process underlying new lesion formation in multiple sclerosis.
Journal ArticleDOI
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
Iain L. Campbell,Carmela R. Abraham,Eliezer Masliah,Phillip Kemper,John D. Inglis,Michael B. A. Oldstone,Lennart Mucke +6 more
TL;DR: Transgenic mice generated in which the cytokine interleukin 6 (IL-6), under the regulatory control of the glial fibrillary acidic protein gene promoter, was overexpressed in the CNS exhibited a neurologic syndrome the severity of which correlated with the levels of cerebral IL-6 expression.
Journal ArticleDOI
Inflammatory mediators and stroke: new opportunities for novel therapeutics.
TL;DR: The realization that brain ischemia and trauma elicit robust inflammation in the brain provides fertile ground for discovery of novel therapeutic agents for stroke and neurotrauma and inhibition of the mitogen-activated protein kinase (MAPK) cascade via cytokine suppressive anti-inflammatory drugs are most promising new opportunities.
References
More filters
Journal ArticleDOI
Cachectin and tumour necrosis factor as two sides of the same biological coin
Bruce Beutler,Anthony Cerami +1 more
TL;DR: The identity of cachectin and tumour necrosis factor has led to a new view of its therapeutic potential and its ability to induce wasting as well as a lethal state of shock.
Journal ArticleDOI
Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
Krzysztof Selmaj,Cedric S. Raine +1 more
TL;DR: It appears that a physiological (not structural) demyelination occurs initially without overt destruction of the myelin sheath, relevant to the evolution of the multiple sclerosis plaque: dysfunction of ionic channels might contribute to the eventual demise of oligodendrocytes and axons in the longstanding lesion.
Journal ArticleDOI
Astrocytes present myelin basic protein to encephalitogenic T-cell lines.
TL;DR: It is shown that rat astrocytes are able to present antigen to T lymphocytes in a specific manner which is restricted by the major histocompatibility complex (MHC) and that they can in particular activate myelin basic protein (BP)-specific, encephalitogenic T-cell lines.
Journal Article
Production of prostaglandin E and an interleukin-1 like factor by cultured astrocytes and C6 glioma cells.
TL;DR: Astrocytes may interact with the immune system by elaborating nonspecific factors that modulate lymphocyte proliferation, which may be important in the generation of specific immune responses in the brain, which is considered to be an immunologically privileged organ.
Journal ArticleDOI
Antigen presentation and tumor cytotoxicity by interferon-γ-treated microglial cells
TL;DR: Microglial cells isolated from brain cell cultures of newborn mice were characterized and investigated for morphology, their responses to growth factors and their functional properties, and taken together they share the characteristics of cells of the macrophage lineage.
Related Papers (5)
Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
Krzysztof Selmaj,Cedric S. Raine +1 more